洛尔类药物的合成及其缓蚀作用机理
Synthesis and Corrosion Inhibition Performance of Bisoprolol Drugs
摘 要
以对羟基苯乙酰胺和1-萘酚为原料分别合成了药物4-[(3-异丙氨基-2-羟基)丙氧基]苯乙酰胺(阿替洛尔)和1-异丙氨基-3-(1-萘氧基)-2-丙醇(普萘洛尔)。采用塔菲尔极化曲线和电化学阻抗谱，研究了它们在25 ℃,1.0 mol·L-1 H2SO4溶液中对A3碳钢的缓蚀作用及机理，并采用量子化学的方法计算了两种分子中原子的电子密度以及前线轨道能量。电化学测试结果表明，两种物质均为阳极抑制为主的混合型缓蚀剂; 同种测试条件下普萘洛尔缓蚀作用强于阿替洛尔。量子化学计算结果表明，普萘洛尔比阿替洛尔具有较高的最高占有轨道能量(HOMO)和较低的最低空轨道能量(LUMO)，具有更优的缓蚀性能，验证了试验结果。
缓蚀剂
电化学方法
量子化学
bisoproiol drug
corrosion inhibitor
electrochemical method
quantum chemistry
Abstract
4-{3-［(1-methylethyl)amino-2-hydroxy］propoxy} phenylacetamide(Atenolol) and 1-［(1-methylethyl)amino］-3-(1-naphthalenyloxy)-2-propanol(Propranolol) were synthesized form 4-hydroxyphenylacetamide and 1-naphthol, respectively. The corrosion inhibition and mechanism of the drugs for mild steel in 1.0 mol·L-1 H2SO4 at 25 ℃ were studied using polarization curves and electrochemical impedance spectroscopy (EIS). The electron density of various atoms and the energy of highest occupied molecular orbital(HOMO) and lowest unoccupied molecular orbital(LUMO) in the molecules were computed by quantum study. The electrochemical results reveal that the two drugs are mix-type inhibitors which mainly inhibit the anodic process. The results of the quantum chemistry calculation show that propranolol has higher energy of the HOMO and lower energy of the LUMO. All the results conclude that propranolol has better inhibition performance than atenolol under the same conditions.
中图分类号 TG174.42
所属栏目 试验研究
基金项目
收稿日期 2013/8/11
修改稿日期
网络出版日期
作者单位点击查看
备注傅佳骏(1980-),研究员,博士,从事缓蚀剂研究,
引用该论文: DU Fang,CAI Ting-ting,XIE Li,HUA Wan-sen,FU Jia-jun. Synthesis and Corrosion Inhibition Performance of Bisoprolol Drugs[J]. Corrosion & Protection, 2014, 35(6): 562
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【6】谢伟,匡飞. 天然绿色缓蚀剂研究进展[J]. 化学工程与装备,2009,11:115-117.
【7】NICOLAE V,VALENTIN O,ALEXANDRA B. Corrosion inhibitors from expired drugs[J]. International Journal of Pharmaceutics,2012,431:241-244.
【8】庞雪辉,李伟华,侯保荣,等. 喹诺酮药品对Q235钢在HCl溶液中缓蚀性能的影响[J]. 中国腐蚀与防护学报,2008,28(3):21-24.
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【15】ZHANG F,TANG Y M,CAO Z Y,et al. Performance and theoretical study on corrosion inhibition of 2-(4-pyridyl)-benzimidazole for mild steel in hydrochloric acid[J]. Corrosion Science,2012,61:1-9.
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【18】宋伟伟,张静,杜敏. 新型不对称双季铵盐缓蚀剂在HCl中对Q235钢的缓蚀行为[J]. 化学学报,2011,16(69):1851-1857.
【19】欧阳礼，颜肖慈，余晓冬，等. 脂肪胺的电子结构与缓蚀性能关系的研究[J]. 中国腐蚀与防护学报,2003,23(6):35-38.
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