镁合金AZ31表面含硅涂层在人工血浆中的降解行为
Degradation of Magnesium Alloy AZ31 with Silicon Coating in Artificial Plasma
摘 要
采用浸涂法在AZ31镁合金表面上制备了含硅涂层; 采用浸泡腐蚀等方法研究了涂层在人工血浆溶液中的腐蚀速率和降解行为, 利用电子探针(EPMA)测定涂层的表面形貌及化学成分, 采用四唑盐(MTT)比色法测定了涂层的细胞毒性。结果表明, 含硅涂层使AZ31镁合金在人工血浆中的腐蚀速率降低到一半, 腐蚀程度降低, 且含硅涂层无细胞毒性。这些结果对其作为血管支架材料有一定的实用意义。
人工血浆
降解
含硅涂层
magnesium alloy
artificial plasma
degradation
silicon coating
Abstract
A silicon coating on magnesium alloy AZ31 was prepared by dipping method. Immersion experiments were carried out to investigate the degradation and corrosion behavior of the silicon coated specimen in artificial plasma medium. The surface morphology and composition were examined by electon proke microanalyzer (EPMA) and the cytotoxicity of the coating was detected by MTT colorimetric assay. The results show that the corrosion rate of magnesium alloy AZ31 with silicon coating was reduced to a half of that without coating. Cytotoxicity was not found out for AZ31 with silicon coating. These results improved the understanding of the degradation mechanism of surgical magnesium used for intravascular stent in the physiological environment.
中图分类号 TG174 R318.08
所属栏目 试验研究
基金项目 上海市科委重大基础研究项目(11DJ1400302)
收稿日期 2013/8/14
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备注李春梅(1981-),工程师,硕士,从事金属材料腐蚀与防护研究,
引用该论文: LI Chun-mei,WEI Zhong-ling,WU Sen,ZHOU Bang-xin. Degradation of Magnesium Alloy AZ31 with Silicon Coating in Artificial Plasma[J]. Corrosion & Protection, 2014, 35(7): 675
被引情况:
【1】李春梅,卫中领,周邦新, "镁合金AZ31表面磷酸盐涂层在人工血浆中的降解行为",腐蚀与防护 36, 461-464(2015)
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【3】李玉宝. 生物医学材料[M]. 北京:化学工业出版社,2003.
【4】THIERRY B,TABRIZIAN M. Biocompatibility and biostability of metallic materials:current status and future perspective[J]. Journal of Endovascular Therapy,2003,10(4):807-824.
【5】王红菊,李霄,张培,等. 镁锌合金骨螺钉表面防降解改性涂层的制备与性能[J]. 机械工程材料, 2013, 37(2): 66-70.
【6】HERMAWAN H, DUB D,MANTOVANI D,et al. Developments in metallic biodegradable stents[J]. Acta Biomaterialia,2010(6):1693-1697.
【7】STAIGER M P,PIETAK A M,HUADMAI J. Magnesium and its alloys as orthopedic biomaterials:a review[J]. Biomaterials,2006,27(9):1728-1734.
【8】李海燕, 李志生, 张世珍, 等. 镁合金的腐蚀与防护研究进展[J]. 腐蚀与防护,2010,31(11):878-881.
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【10】SAKKA S,KAMIYA K,MAKITA K,et al. Formation of sheets and coating films from alkoxide solutions[J]. Journal of Non-Crystalline Solids,1984,63:223-235.
【11】叶红齐,陈加娜,刘辉,等. 片状铝粉表面包覆SiO2薄膜的研究[J]. 上海涂料,2006,44(10):15-18.
【12】郑国华,罗新乐. 无支撑体SiO2膜的制备及其表征[J]. 新疆大学学报:自然科学版,2006,23(4):437-476.
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