掺杂硒修饰碳糊电极伏安法测定对乙酰氨基酚
Voltammetric Determination of Acetaminophen Using Carbon Paste Modified Electrode Doped with Selenium
摘 要
采用循环伏安法制备了掺杂硒修饰碳糊电极,用循环伏安法和差分脉冲伏安法研究了对乙酰氨基酚在掺杂硒修饰碳糊电极上的电化学行为,建立了掺杂硒修饰碳糊电极测定对乙酰氨基酚的电化学方法。在pH 4.6的0.1 mol·L-1乙酸-乙酸钠缓冲溶液中,对乙酰氨基酚在+0.61 V呈现一个灵敏的氧化峰。对乙酰氨基酚的浓度在6.0×10-7~1.5×10-4mol·L-1范围内与其氧化峰电流呈线性关系,检出限(3s/k)为2.8×10-7mol·L-1。方法用于药品中对乙酰氨基酚的测定,测定结果与药典法测定值相符,测定值的相对标准偏差(n=5)在2.1%~2.5%之间。
掺杂硒修饰碳糊电极
对乙酰氨基酚
Voltammetry
Carbon paste modified electrode doped with selenium
Acetaminophen
Abstract
Carbon paste modified electrode doped with selenium was prepared by cyclic voltammetry, and the electrochemical behavior of acetaminophen (ACOP) at this electrode was studied by cyclic voltammetry and differential pulse voltammetry. A cyclic voltammetric method for the determination of ACOP with carbon paste modified electrode doped with selenium was established. In 0.1 mol·L-1 HOAc-NaOAc buffer solution of pH 4.6, a sensitive oxidation peak of ACOP at +0.61 V (vs.SCE) was observed. Linear relationship between values of oxidation peak current and concentration of ACOP was kept in the range of 6.0×10-7-1.5×10-4mol·L-1 with detection limit (3s/k) of 2.8×10-7mol·L-1. The proposed method was applied to the analysis of tablet samples, giving results in consistency with the values obtained by pharmacopoeia method with RSD′s (n=5) in the range of 2.1%-2.5%.
中图分类号 O657.14
所属栏目 工作简报
基金项目 国家自然科学基金项目(21165007);广西矿冶与环境科学实验中心项目(KH2012YB003)
收稿日期 2013/9/13
修改稿日期
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备注谭君林(1985-),男,广西玉林人,硕士,主要研究方向为电化学分析与生物传感器。
引用该论文: TAN Jun-lin,ZHANG Lian-ming,HU Cun-jie,WEI Xiao-ping. Voltammetric Determination of Acetaminophen Using Carbon Paste Modified Electrode Doped with Selenium[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2014, 50(9): 1081～1085
谭君林,张连明,胡存杰,魏小平. 掺杂硒修饰碳糊电极伏安法测定对乙酰氨基酚[J]. 理化检验－化学分册, 2014, 50(9): 1081～1085
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【4】陈红,李来生,张杨,等.厚朴酚键合相HPLC测定纳尔平中的愈创木酚磺酸钾、对乙酰氨基苯酚及咖啡因［J］.分析试验室, 2012,31(11):67-71．
【5】吴美艳,李利军,胡大春,等.在线扫集-胶束毛细管电动色谱法测定复方氨酚烷胺胶囊中的3种有效成分［J］.分析测试学报, 2012,31(3):284-289．
【6】王书民,樊雪梅,杨喆,等.KMnO4-甲醛化学发光体系测定对乙酰氨基酚［J］.分析试验室, 2012,31(6):20-23．
【7】HUANG Sha-sheng, TANG He, LI Fen-bi. Electrochemistry of electropolymerized tetra (p-aminophenyl)porphyrin nickel film electrode and catalytic oxidation of acetaminophen［J］. Microchim Acta, 1998,128(1/2):37-42．
【8】李利军,钟亮,蔡卓,等.对乙酰氨基酚在多壁碳纳米管L-半胱氨酸共组装修饰金电极上的电化学行为研究及其测定［J］.分析化学, 2008,36(12):1651-1656．
【9】DUARTE E H, KUBOTA L T, TARLEY C R T. Carbon nanotube based sensor for simultaneous determination of acetaminophen and ascorbic acid exploiting multiple response optimization and measures in the presence of surfactant［J］. Electroanalysis, 2012,24(12):2291-2301．
【10】SHANGGUAN Xiao-dong, ZHANG Hong-fang, ZHENG Jian-bin. Electrochemical behavior and differential pulse voltammetric determination of paracetamol at a carbon ionic liquid electrode［J］. Anal Bioanal Chem, 2008,391(3):1049-1055．
【11】李建平,高会玲,熊志刚.磁性纳米金共价固定癌胚抗原单克隆抗体的电流型免疫传感器［J］.高等学校化学学报, 2008,29(11):2149-2154．
【12】NEMATOLLAHI D, SHAYANI-JAM H, ALIMORADI M, et al. Electrochemical oxidation of acetaminophen in aqueous solutions: kinetic evaluation of hydrolysis, hydroxylation and dimerization processes［J］. Electrochim Acta, 2009,54(28):7407-7415．
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【14】王朝霞,陈美凤,马心英.β-丙氨酸-银复合膜修饰电极用于循环伏安法测定对乙酰氨基酚［J］.理化检验-化学分册, 2012,48(5):530-533．
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