Differential Pulse Voltammetric Determination of Acetaminophen with Poly-p-Aminobenzene Sulfonic Acid Modified Electrode
摘 要
在由pH 7.0的磷酸盐缓冲溶液和2.0×10-3mol·L-1对氨基苯磺酸组成的支持电解质中,以100 mV·s-1扫描速率在玻碳电极上先后在电位-1.5~2.5 V范围内循环扫描10周、在电位-1.5~1.5 V范围内循环扫描15 min,制得聚对氨基苯磺酸修饰的玻碳电极。循环伏安法研究发现:对乙酰氨基酚在该修饰电极上出现了一对氧化还原峰,两峰的电位差为30 mV;差分脉冲伏安法研究发现:在pH 5.9的磷酸盐缓冲溶液中,对乙酰氨基酚在0.295 V处出现一良好的氧化峰。且乙酰氨基酚的浓度在2.0×10-7~1.0×10-5mol·L-1范围内与峰电流呈线性关系,检出限(3S/N)为9.0×10-8mol·L-1。据此提出了差分脉冲伏安法测定药片中对乙酰氨基酚的含量,3个样品的测定结果与标示值相符,测得平均回收率为98.6%,相对标准偏差(n=6)均小于3.5%。
Abstract
Poly-p-aminobenzene sulfonic acid modified glassy carbon electrode (GCE) was prepared by cyclic voltammetry (CV) with scanning rate of 100 mV·s-1 in an electrolyte containing PBS of pH 7.0 and 2.0×10-3mol·L-1 p-aminobenzene sulfonic acid solution for 10 cycles first in the potential range of -1.5-2.5 V and then in the potential range of -1.5-1.5 V for 15 min. As shown by the result of CV study on the electrochemical behavior ACOP at the modified electrode, a pair of oxidation and reduction peaks was found giving a potential difference of 30 mV. It was shown by DPV study in PBS of pH 5.9 that a sensitive oxidation peak of ACOP was observed at the potential of 0.295 V (vs.SCE), and linear relationship between values of peak current at this potential and concentration of ACOP was obtained in the range of 2.0×10-7-1.0×10-5mol·L-1, with value of detection limit (3S/N) of 9.0×10-8mol·L-1. Based on these facts, the DPV method was used in the determination of ACOP in its tablets. In analyzing 3 tablet samples of the drug, results in consistency with the labelled value were obtained. Average value of recovery test obtained was 98.6%, with RSD′s (n=6) less than 3.5%.
中图分类号 O657.1
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基金项目 商洛学院资助项目(10SKY015)
收稿日期 2010/2/25
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备注王书民(1966-),男,陕西渭南人,副教授,研究方向为分析化学。
引用该论文: WANG Shu-min,FAN Xue-mei,DONG Wen-ju. Differential Pulse Voltammetric Determination of Acetaminophen with Poly-p-Aminobenzene Sulfonic Acid Modified Electrode[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2011, 47(4): 445~448
王书民,樊雪梅,董文举. 聚对氨基苯磺酸修饰电极差分脉冲伏安法测定对乙酰氨基酚[J]. 理化检验-化学分册, 2011, 47(4): 445~448
被引情况:
【1】顾玲,张苗,贺亚梅, "聚硫堇/亚铁氰根修饰碳糊电极的研制及其在维生素B6测定中的应用",理化检验-化学分册 49, 521-525(2013)
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参考文献
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【2】NI Yong-nian, LIU Chao, SERGE K. Simultaneous kinetic spectrophotometric determination of acetaminophem and phenobarbital by artificial neural networks and partial least squares[J]. Anal Chim Acta, 2000,419(5):185-196.
【3】MATIN A, BARBAS C. CE versus HPLC for the dissolution test in a pharmaceutical form ulation containing acetaminophen, phenylephrine and chlorpheniramine[J]. J Pharm Biomed Anal, 2004,35(12):769-777.
【4】KUNKEL A, WATZIG H. Pharmacokinetic investigations with direct injection of plasma samples:Possible savings using capillary dectmphoresis(CE)[J]. Archiv der Pharmazie, 1999,332(10):175-178.
【5】PULGARIN J A M, BERMEJO L F G. Flow-injection stoppedflow spectrofluofimetric kinetic determination of paracetamol based on its oxidation reaction by hexacyanoferrate (Ⅲ)[J]. Anal Chim Acta, 1996,333(6):59-69.
【6】BOOPATHI M, MISOOK W, YOONBO S. A sensor for acetaminophen in a blood medium using a Cu(Ⅱ)-conducting polymer complex modified electrode[J]. Anal Chim Acta, 2004,512(18):191-197.
【7】WANGFUENGKANAGUL N, CHAILAPAKUL O. Electrochemical analysis of acetaminophen using a boron-doped diamond thin film electrode applied to flow injection system[J]. J Pharm Biomed Anal, 2002,28(4):841-847.
【8】JYHMYNG Z, YUANSHIH T. Simultaneous determination of cafeine and acetaminophen in drug formulations by square-wave voltammetry using a chemically modified electrode[J]. Anal Chim Acta, 1997,342(10):175-180.
【9】汪振辉,张岱,张岩,等.聚吖啶红修饰电极的制备及其应用[J].应用化学, 2004,21(8):566-570.
【10】段连生,曾国平.对乙酰氨基酚在碳纳米管粉末微电极上的电化学行为[J].应用化学, 2008,25(12):1464-1467.
【11】LI Ming-qi, JING Lin-hei. Electrochemical behavior of acetaminophen and its detection on the PANI-MWCNTs composite modified electrode[J]. Electrochimica Acta, 2007,52(12):3250-3257.
【12】ERDOGDU G, KARAGTVZLER A E. Investigation and comparison of the electrochemical behavior of some orgarric and biological molecules at various conducting polymer electrodes[J]. Talanta, 1997,44(11):2011-2018.
【13】汪振辉,张永花,周漱萍.对乙酰氨基酚在导电聚合物修饰电极上的电化学行为及其伏安测定[J].药学学报, 2001,36(11):840-843.
【14】王正国.聚-L丝氨酸修饰电极伏安法测定对乙酰氨基酚[J].化学研究与应用, 2006,18(9):1095-1098.
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