流动注射-化学发光法测定扑热息痛
FI-Chemiluminescence Determination of Paracetamol
摘 要
基于在0.5 mol·L-1氢氧化钠介质中,扑热息痛对鲁米诺-过氧化氢体系的化学发光具有显著的抑制作用,提出了流动注射-化学发光法测定扑热息痛含量的方法。在优化的试验条件下,扑热息痛的化学发光强度与其质量浓度在4.5×10-5~1.5×10-2g·L-1范围内呈线性关系,方法的检出限(3σ)为9.0×10-7g·L-1。此法用于扑热息痛片的分析,测得加标回收率在93.3%~106.7%之间,测定值的相对标准偏差(n=6)在2.6%~3.0%之间。
化学发光法
扑热息痛
鲁米诺
过氧化氢
Flow injection
Chemiluminescence
Paracetamol
Luminol
Hydrogen peroxide
Abstract
Based on the inhibitory effect of paracetamol on the CL-reaction system of luminol-H2O2 in 0.5 mol·L-1 NaOH medium, a method for the determination of paracetamol by FI-chemiluminescence (CL) was proposed. Under the optimum conditions, linear relationship of values of CL intensity and mass concentration of paracetamol was obtained in the range of 4.5×10-5-1.5×10-2g·L-1, with detection limit (3σ) of 9.0×10-7g·L-1. The proposed method was applied to the analysis of paracetamol tablets, giving values of recovery by standard addition method in the range of 93.3%-106.7% and RSD (n=6) in the range of 2.6%-3.0%.
中图分类号 O657.3
所属栏目
基金项目 商洛学院资助项目(11SKY001)
收稿日期 2011/8/10
修改稿日期
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备注樊雪梅(1980-),女,陕西渭南人,讲师,研究方向为分析化学。
引用该论文: FAN Xue-mei,WANG Shu-min,SU Zhi-kui,CHEN Feng-ying,LIU Ping,WANG Xian-sheng. FI-Chemiluminescence Determination of Paracetamol[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2011, 47(10): 1149～1151
樊雪梅,王书民,苏智魁,陈凤英,刘萍,王宪生. 流动注射-化学发光法测定扑热息痛[J]. 理化检验－化学分册, 2011, 47(10): 1149～1151
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参考文献
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【10】LI Ming-qi, JING Lin-hai. Electrochemical behavior of acetaminophen and its detection on the PANI-MWCNTs composite modified electrode［J］. Electrochimica Acta, 2007,52(12):3250-3257.
【11】NATTAKARN W, ORAWON C. Electrochemical analysis of acetaminophen using a boron-doped diamond thin film electrode applied to flow injection system［J］. Journal of Pharmaceutical and Biomedical Analysis, 2002,28(4):841-847.
【12】RUENGSITAGOON W, LIAWRUANGRATH S, TOWNSHEND A. Flow injection chemiluminescence determination of paracetamol［J］. Talanta, 2006,69(4):976-983.
【13】陈华,章竹君,付志锋.流动注射化学发光法测定扑热息痛［J］.分析化学, 2002,30(11):1344-13.
【2】Ni Yong-nian, LIU Chao, KOKOT S. Simultaneous kinetic spectrophotometric determination of acetaminophem and phenobarbital by artificial neural networks and partial least squares［J］. Anal Chim Acta, 2000,419(2):185-196.
【3】MATIN A, BARBAS C. CE versus HPLC for the dissolution test in a pharmaceutical formulation containing acetaminophen, phenylephrine and chlorpheniramine［J］. Journal of Pharmaceutical and Biomedical Analysis, 2004,35(4):769-777.
【4】KUNKEL A, WATZIG H. Pharmacokinetic investigations with direct injection of plasma samples:Possible savings using capillary electophoresis(CE)［J］. Archiv der Pharmazie, 1999,332(5):175-178.
【5】LLORENT-MARTNEZ E J, ATNSK D, SOLICH P, et al. Fluorimetric SIA optosensing in pharmaceutical analysis: determination of paracetamol［J］. Journal of Pharmaceutical and Biomedical Analysis, 2007,45(2):318-321.
【6】PULGARIN J A M, BERMEJO L F G. Flow-injection stoppedflow spectrofluofimetric kinetic determination of paracetamol based on its oxidation reaction by hexacyanoferrate (Ⅲ)［J］. Anal Chim Acta, 1996,333(6):59-69.
【7】段连生,曾国平.对乙酰氨基酚在碳纳米管粉末微电极上的电化学行为［J］.应用化学, 2008,25(12):1464-1467.
【8】LI Ming-qi, JING Lin-hai. Electrochemical behavior of acetaminophen and its detection on the PANI-MWCNTs composite modified electrode［J］. Electrochimica Acta, 2007,52(9):3250-3257.
【9】BOOPATHI M, MISOOK W, YOONBO S. A sensor for acetaminophen in a blood medium using a Cu(Ⅱ)-conducting polymer complex modified electrode［J］. Anal Chim Acta, 2004,512(18):191-197.
【10】LI Ming-qi, JING Lin-hai. Electrochemical behavior of acetaminophen and its detection on the PANI-MWCNTs composite modified electrode［J］. Electrochimica Acta, 2007,52(12):3250-3257.
【11】NATTAKARN W, ORAWON C. Electrochemical analysis of acetaminophen using a boron-doped diamond thin film electrode applied to flow injection system［J］. Journal of Pharmaceutical and Biomedical Analysis, 2002,28(4):841-847.
【12】RUENGSITAGOON W, LIAWRUANGRATH S, TOWNSHEND A. Flow injection chemiluminescence determination of paracetamol［J］. Talanta, 2006,69(4):976-983.
【13】陈华,章竹君,付志锋.流动注射化学发光法测定扑热息痛［J］.分析化学, 2002,30(11):1344-13.
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