提出了阳极吸附伏安法测定盐酸莫西沙星的方法。在pH 6.55的B-R缓冲溶液中,开路富集120 s后,盐酸莫西沙星在碳糊电极表面于0.987 V(vs.SCE)处产生一灵敏的氧化峰,该氧化峰电流与盐酸莫西沙星浓度在5.6×10-7~1.0×10-5mol·L-1范围内呈线性关系,其检出限(3s/k)为4.3×10-8mol·L-1。方法用于模拟片剂样品中盐酸莫西沙星的测定,测定值与标示值相符,其相对标准偏差(n=6)为3.8%,以健康人尿液为基体做加标回收试验,测得平均回收率为101.6%。

Anodic adsorptive voltammetry was applied to the determination of moxifloxacin hydrochloride (MF). In a B-R buffer solution of pH 6.55, the adsorptive voltammetric behavior of MF at the carbon paste electrode was studied after open-circuit accumulation for 120 s, a sensitive oxidation peak was observed at 0.987 V (vs.SCE). Linear relationship between values of oxidation peak current and concentration of MF was kept in the range of 5.6×10-7-1.0×10-5mol·L-1. Detection limit (3s/k) found for the method was 4.3×10-8mol·L-1. The proposed method was used in the determination of MF in its tablets, giving results in consistency with the labelled value, with values of RSD′s (n=6) 3.8%. Recovery was tested by addition of standards to urine sample of healthy person, and the result of average recovery found was 101.6%.