Preparation and Application of a Potentiometric Sensor for Determination of Sibutramine Hydrochloride
摘 要
以四苯硼酸钠与盐酸西布曲明生成的离子缔合物为电活性物质,研制了盐酸西布曲明传感器。试验表明:盐酸西布曲明聚氯乙烯(PVC)膜传感器对盐酸西布曲明具有良好的选择性和电位响应特性。在pH 5的溶液中,电极电位呈现近能斯特响应,线性范围为1.0×10-6~1.0×10-1mol·L-1,斜率为50 mV·pc-1(26 ℃),检出限(3S/N)为5.62×10-7mol·L-1。将电极用于药物中盐酸西布曲明含量的测定,测得回收率为97.3%~100.2%,测定值的相对标准偏差(n=5)均小于2%。
Abstract
By using the ion association complex formed between sibutramine hydrochloride and sodium tetraphenylborate as electroactive substance, and polyvinyl chloride (PVC) membrane as carrier, a potentiometric sensor was prepared, showing selective potential response toward sibutramine hydrochloride in the range of 1.0×10-6-1.0×10-1mol·L-1 with detection limit (3S/N) of 5.62×10-7mol·L-1, and slope of 50 mV·pc-1 in a solution of pH 5 at 26 ℃. Recovery of the method was tested by standard addition method on the base of samples of sibutramine hydrochloride drug, results of recovery found were in the range of 97.3%-100.2% with RSD′s (n=5) less than 2%.
中图分类号 O657.1
所属栏目 工作简报
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收稿日期 2011/4/17
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联系人作者徐刚(xgxyt@163.com)
备注徐刚(1972-),男,贵州遵义人,硕士,高级工程师,主要研究方向为分析测试技术。
引用该论文: XU Gang,DONG Wen-li,REN Ling-yan. Preparation and Application of a Potentiometric Sensor for Determination of Sibutramine Hydrochloride[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2012, 48(4): 456~458
徐刚,董文丽,任凌燕. 测定盐酸西布曲明的电位传感器的研制与应用[J]. 理化检验-化学分册, 2012, 48(4): 456~458
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参考文献
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【3】黄芳,陈华,夏之宁.西布曲明对映体的毛细管电泳分离与定量分析方法研[J].药物分析杂志, 2004,24(2):113-116.
【4】DING Li, HAO Xin-yu, HUANG Xin, et al. Simultaneous determination of sibutramine and its N-desmethyl metabolites in human plasma by liquid chromatography-electrometry ionization-mass spectrometry method and clinical applications[J]. Anal Chim Acta, 2003,492(1/2):241-248.
【5】权伍英,栾燕,张欣.LC-MS/MS检测减肥保健品中的盐酸芬氟拉明和盐酸西布曲明[J].中国卫生检验杂志, 2007,17(1):10-12.
【6】刘吉金,李军.减肥食品或保健品中非法添加盐酸西布曲明、盐酸芬氟拉明、酚酞的快速检测方法研究[J].药物分析杂志, 2006,26(6):793-794.
【7】秦宗会,谭蓉.溴甲酚绿光度法测定曲美胶囊中的盐酸西布曲明[J].工业卫生与职业病, 2007,33(6):371-373.
【8】秦宗会,谭蓉,蒲利军,等.刚果红褪色光度法测定盐酸西布曲明及作用机理研究[J].分析化学, 2006,34(3):403-406.
【9】HORNING E C. Org Synth Coll Vol Ⅲ[M]. NewYork: John Wiley, 1955:140.
【10】徐晓贤,COSFRET V V,章宗穰.药物传感器的交流阻抗谱研究[J].化学传感器, 1991,11(1):45-50.
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