Electrochemiluminescence Determination of Chlorpheniramine Maleate with Tri-(2,2′-bipyridyl)ruthenium Composite Film Modified Electrode
摘 要
以氧化铟锡(ITO)导电玻璃为基质,研制了一种SiO2/Ppy/PSS/Ru(bpy)32+复合膜修饰电极。在pH 8.00磷酸盐缓冲溶液中,马来酸氯苯那敏(CM)在修饰电极的电化学发光强度(ECL)有强增敏作用,据此建立了一种灵敏地测定马来酸氯苯那敏的电化学发光的方法。其ECL增加程度与CM的浓度在30~100 μmol·L-1之间呈线性关系。方法的检出限(3S/N)为9.0×10-2μmol·L-1。对2.0 μmol·L-1马来酸氯苯那敏标准溶液连续测定11次,测定值的相对标准偏差为1.3%。方法用于维C银翘片中马来酸氯苯那敏的测定,回收率在96.5%~98.8%之间。
Abstract
A SiO2/Ppy/PSS/Ru(bpy)32+ composite film modified electrode was fabricated using indium tin oxide (ITO) conductive glass as the substrate. Based on the significant enhancement of electrochemiluminescence of chlorpheniramine maleate (CM) at the composite film modified electrode in a PBS of pH 8.00, a highly sensitive electrochemiluminescence (ECL) method was proposed for the determination of CM. Linear relationship between magnitude of enhancement of ECL intensity and concentration of CM was obtained in the range of 30-100 μmol·L-1, with value of detection limit (3S/N) for CM of 9.0×10-2μmol·L-1. Values of RSD (n=11) found with a same modified electrode in successive determinations of 2.0 μmol·L-1 CM standard solution was 1.3%. The proposed method was applied to the determination of CM in “Vitamin C Yinqiao” tablet, giving values of recovery in the range of 96.5%-98.8%.
中图分类号 O657.1
所属栏目 工作简报
基金项目 国家自然科学基金(20675036);山东省自然科学基金(Y2006B04)
收稿日期 2012/2/20
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联系人作者张真真(cgfu@lcu.edu.cn)
备注张真真(1984-),女,山东高唐人,硕士研究生,主要从事电化学发光技术研究。
引用该论文: ZHANG Zhen-zhen,FU Chong-gang,WANG Li-xin. Electrochemiluminescence Determination of Chlorpheniramine Maleate with Tri-(2,2′-bipyridyl)ruthenium Composite Film Modified Electrode[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2012, 48(6): 660~663
张真真,傅崇岗,王立新. 三联吡啶钌复合膜修饰电极电化学发光法测定马来酸氯苯那敏[J]. 理化检验-化学分册, 2012, 48(6): 660~663
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【5】GREENWAY G M, NELSTROP L J, PORT S N. Tris(2,2-bipyridyl)ruthenium(Ⅱ) chemiluminescence in a microflow injection system for codeine determination[J]. Anal Chim Acta, 2000,405:43-49.
【6】GUO Zhi-hui, SHEN Yan, WANG Ming-kui, et al. Electrochemistry and electrogenerated chemiluminescence of SiO2 nanoparticles/tris-(2,2′-bipyridyl)ruthenium(Ⅱ) multilayer filma on indium tin oxide electrode[J]. Anal Chem, 2004,76(1):184-191.
【7】GORMAN B A, FRANCIS P S, BARNETT N W. Tris(2,2-bipyridyl)ruthenium(Ⅱ) chemiluminescence[J]. Analyst, 2006,131:616-639.
【8】YU Jia-guo, FAN Fu-ren, PAN Shan-lin, et al. Spontaneous formation and electrogenerated chemiluminescence of tris(bipyridine) Ru(Ⅱ) derivative nanobelts[J]. J Am Chem Soc, 2008,130(23):7196-7197.
【9】SHI Li-hong, LIU Xiao-qing, LI Hai-juan, et al. Electrochemiluminescent detection based on solid-phase extraction at tris(2,2′-bipyridyl) ruthe-nium(Ⅱ)-modified ceramic carbon electrode[J]. Anal Chem, 2006,78:7330-7334.
【10】KIM D J, LYU Y K, CHOI H N, et al. Nafion-stabilized magnetic nanoparticles (Fe3O4) for [Ru(bpy)3]2+(bpy=bipyridine) electrogenerated chemiluminescence sensor[J]. Chem Comm, 2005,23:2966-2968.
【11】MARTIN A F, NIEMAN T A. Chemiluminescence biosensors using tris-(2,2′-bipyridyl)-ruthenium(Ⅱ) and dehydrogenases immobilized in cation exchange polymers[J]. Biosens Bioelectron, 1997,12(6):479-489.
【12】CAO Wei-dong, JIA Jian-bo, YANG Xiu-rong, et al. Capillary electrophoresis with solid-state electrochemiluminescence detector[J]. Electrophoresis, 2002,23(21):3692-3698.
【13】时雨荃,张淑芬,胡明,等.化学氧化法合成聚吡咯的热分析研究[J].高分子材料科学与工程, 2007,17:153-156.
【14】MIAO W J, CHOI J P, BARD A J. Electrogenerated chemiluminescence 69: The tris(2,2′-bipyridine) ruthenium(Ⅱ), (Ru(bpy)32+)/Tri-n-propylamine (TPrA) system revisited-A new route involving TPrA+ cation radicals[J]. J Am Chem Soc, 2002,124:14478-14485.
【15】ZU Y, BARD A J. Electrogenerated chemiluminescence. The role of direct coreactant oxidation in the ruthenium tris(2,2′-bipyridyl) tripropylamine system and the effect of Halid ions on the emission intensity[J]. Anal Chem, 2000,72:3223-3232.
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