用线性扫描极谱法研究盐酸乙哌立松的电化学行为。在pH 4.73的0.15 mol·L-1乙酸-乙酸钠缓冲溶液中,盐酸乙哌立松于-1.269 V(vs.SCE)处产生一灵敏的吸附波,其一次微分线性扫描峰电流与盐酸乙哌立松质量浓度在0.050~250.0 mg·L-1范围内呈线性关系,检出限(3S/N)为0.040 mg·L-1。对50.0 mg·L-1盐酸乙哌立松溶液进行6次平行试验,相对标准偏差(n=6)为0.98%,方法可用于其片剂中盐酸乙哌立松含量的测定。

It was found that in an acetate buffer solution of pH 4.73 and by the linear scanning polarography, a sensitive adsorption wave of eperisone hydrochloride was observed at the potential of -1.269 V (vs.SCE). Linear relationship between values of the 1st derivative of peak current and mass concentration of eperisone hydrochloride was obtained in the range of 0.05-250.0 mg·L-1 with detection limit (3S/N) of 0.04 mg·L-1. Precision was tested with standard solution of eperisone hydrochloride of 50.0 mg·L-1 for 6 determinations, value of RSD found was 0.98%. The proposed method has been used in the determination of content of eperisone hydrochloride in its tablets.