用线性扫描极谱法研究盐酸吡硫醇的电化学行为,在pH 6.27的磷酸氢二钠-磷酸二氢钾缓冲溶液中,盐酸吡硫醇于-0.560 V(vs.SCE)处产生一灵敏的吸附波,其一次微分线性扫描峰电流与盐酸吡硫醇质量浓度在0.10~100.0 mg·L-1范围内呈线性关系,检出限(3S/N)为0.07 mg·L-1。对10.0 mg·L-1盐酸吡硫醇溶液进行6次平行试验,相对标准偏差为0.82%,方法可用于片剂中盐酸吡硫醇含量的测定,所得结果与标示值相符。

It was found that in a PBS of pH 6.27 and by the linear scanning polarography, a sensitive adsorption wave of pyritinol hydrochloride was observed at the potential of -0.560 V (vs.SCE). Linear relationship between values of the 1st derivative of peak current and mass concentration of pyritinol hydrochloride was obtained in the range of 0.1-100.0 mg·L-1 with detection limit (3S/N) of 0.07 mg·L-1. Precision was tested with standard solution of pyritinol hydrochloride of 10.0 mg·L-1 for 6 determinations, value of RSD found was 0.82%. The proposed method has been used in the determination of content of pyritinol hydrochloride in its tablets, giving results in consistency with the labelled values.