GC Determination of Isobutyl Nitrite and Amyl Nitrite in Cosmetics
摘 要
提出了气相色谱法同时测定化妆品中禁用物质亚硝酸异丁酯和亚硝酸戊酯的含量。化妆品样品中加入20 g·L-1亚硫酸钠溶液1.0 mL后,用丙酮超声提取10 min,从所得提取液中分取2 μL进样进行气相色谱分析,用氢火焰离子化检测器检测。方法的线性范围在10.00~1 000 mg·L-1之间,亚硝酸异丁酯和亚硝酸戊酯的检出限分别(3S/N)为4 μg·g-1和2 μg·g-1。按标准加入法做回收试验,所得回收率分别为87.1%~98.8%和86.8%~96.9%之间,测定值的相对标准偏差(n=9)均小于5.0%。
Abstract
A method of GC for simultaneous determination of two banned esters of nitrous acid (i.e., isobutyl nitrite and amyl nitrite) in cosmetics was proposed. The sample was added with 1.0 mL 20 g·L-1 of sodium sulfite solution and extracted ultrasonically for 10 min with acetone. Two uL of the extract were used for GC analysis, with flame ionization detection (FID). Linearity range of the method was kept between 10.00 to 1 000 mg·L-1, with detection limits (3S/N) of 4 μg·g-1 for isobutyl nitrite and 2 μg·g-1 for amyl nitrite. Tests for recovery were made by standard addition method, giving values of recovery in the range of 87.1%-98.8% and 86.8%-96.9% respectively, with RSD′s (n=9) less than 5.0%.
中图分类号 O657.7
所属栏目 工作简报
基金项目 公益性行业(国家质量监督检验检疫总局)科研专项资助项目(2009424267)
收稿日期 2011/11/8
修改稿日期
网络出版日期
作者单位点击查看
备注闫俊秀(1985-)女,安徽人,硕士研究生,研究方向为香料香精与化妆品的分析及安全性评价。
引用该论文: YAN Jun-xiu,LI Qiong,CUI Jian-jie,WU Xiao-jian. GC Determination of Isobutyl Nitrite and Amyl Nitrite in Cosmetics[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2013, 49(2): 222~224
闫俊秀,李琼,崔俭杰,武晓剑. 气相色谱法测定化妆品中亚硝酸异丁酯和亚硝酸戊酯[J]. 理化检验-化学分册, 2013, 49(2): 222~224
共有人对该论文发表了看法,其中:
人认为该论文很差
人认为该论文较差
人认为该论文一般
人认为该论文较好
人认为该论文很好
参考文献
【1】赵同刚.化妆品卫生规范[M].北京:军事医学科学出版社, 2007.
【2】KIELBASA W B, BAUER J A, FUNG Ho-leung. Analysis of isobutyl nitrite inhalant in rat and human blood: application for pharmacokinetic investigations[J]. Journal of Chromatography B, 1999,734:83-89.
【3】WATANABE-SUZUKI K, NOZAWA H, SUZUKI O. Sensitive analysis of alkyl alcohols as decomposition products of alkyl nitrites in human whole blood and urine by headspace capillary GC with cryogenic oven trapping[J]. Journal of Chromatographic Science, 2003,41:1-4.
【4】SETO Y. Alkyl nitrites[M]. Birkhuser: Drugs and Poisons in Humans II, 2005.
【2】KIELBASA W B, BAUER J A, FUNG Ho-leung. Analysis of isobutyl nitrite inhalant in rat and human blood: application for pharmacokinetic investigations[J]. Journal of Chromatography B, 1999,734:83-89.
【3】WATANABE-SUZUKI K, NOZAWA H, SUZUKI O. Sensitive analysis of alkyl alcohols as decomposition products of alkyl nitrites in human whole blood and urine by headspace capillary GC with cryogenic oven trapping[J]. Journal of Chromatographic Science, 2003,41:1-4.
【4】SETO Y. Alkyl nitrites[M]. Birkhuser: Drugs and Poisons in Humans II, 2005.
相关信息