鲁米诺-高锰酸钾体系化学发光法测定富马酸酮替芬
Determination of Ketotifen Fumarate Based on the Chemiluminescence Reaction of Luminol with Potassium Permanganate
摘 要
基于富马酸酮替芬对碱性条件下高锰酸钾-鲁米诺化学发光体系的增敏作用,结合流动注射技术,建立了测定富马酸酮替芬的化学发光法.在优化的试验条件下,增敏化学发光强度的比值与富马酸酮替芬的浓度在1.8×10-8~2.0×10-6mol·L-1范围内呈线性关系,方法的检出限(3s/k)为5.6×10-9mol·L-1.加标回收率在98.6%~102%之间,测定值的相对标准偏差在1.1%~1.4%之间.方法用于分析市售富马酸酮替芬片剂,测定值与标示值相符.
富马酸酮替芬
鲁米诺
高锰酸钾
流动注射
Chemiluminescence
Ketotifen fumarate
Luminol
Potassium permanganate
Flow injection
Abstract
A mehod of flow-injection chemiluminescence was developed for the determination of ketotifen fumarate,based on the fact that ketotifen fumarate could enhance the chemiluminescence intensity of the luminol-KMnO4 system obviously. Under the optimum conditions,the ratio of chemiluminescence intensity (I/I0) was correlated linearly with the concentration of ketotifen fumarate in the range of 1.8×10-8-2.0×10-6mol·L-1 and the detection limit (3s/k) was 5.6×10-9mol·L-1. The recovery rates measured by standard addition method were in the range of 98.6%-102%,and RSD were in the range of 1.1%-1.4%.The method was used to analyzing commercially available ketotifen fumarate tablets,giving results in agreement with the indicated value.
中图分类号 O657.3 DOI 10.11973/lhjy-hx201507027
所属栏目 专题报道(药物分析)
基金项目 陕西省自然科学基础研究计划项目(2014JM2056)
收稿日期 2014/7/11
修改稿日期
网络出版日期
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备注张向亮(1990-),女,陕西富平人,硕士研究生,主要研究方向为发光分析.
引用该论文: ZHANG Xiang-liang,MA Hong-yan,WANG Yan-ni,WANG Gang,GAO Chun-yan. Determination of Ketotifen Fumarate Based on the Chemiluminescence Reaction of Luminol with Potassium Permanganate[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2015, 51(7): 999～1002
张向亮,马红燕,王艳妮,王刚,高春燕. 鲁米诺-高锰酸钾体系化学发光法测定富马酸酮替芬[J]. 理化检验－化学分册, 2015, 51(7): 999～1002
被引情况:
【1】努尔古再丽·艾则孜,姜 娜,李桂新, "用鲁米诺功能化金纳米粒子修饰的金电极电化学发光法测定多巴胺",理化检验－化学分册 52, 378-383(2016)
【2】袁 华,杨凤珍,范小振, "高锰酸钾-甲醛-酚磺乙胺体系化学发光法测定酚磺乙胺的含量",理化检验－化学分册 52, 837-839(2016)
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参考文献
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【2】陈晓莉,文爱东,赵磊,等.富马酸酮替芬分散片在健康人体的药动学及生物等效性评价[J].第四军医大学学报,2004,25(18):670-1672．
【3】SINGHVI I,SACHDEVA D. Spectrophotometric estimation of ketotifen fumarate from tablet formulations[J]. Indian Journal of Pharmaceutical Sciences,2009,71(1):66-68．
【4】陈桂良,瞿华.HPLC法测定复方安乃近片中富马酸酮替芬的含量[J].药物分析杂志,2003,23(2):123-126．
【5】陈江涛,廖强.反相高效液相色谱法测定富马酸酮替芬滴鼻液的含量[J].中国药业,2011,20(9):23-23．
【6】KHATER M M,ISSA Y M,SABREIN H,et al. Flow injection determination of ketotifen fumarate using PVC membrane selective electrodes[J]. Bioelectrochemistry,2009,77(1):53-59．
【7】徐杰远.毛细管电泳法测定富马酸酮替芬糖浆中富马酸酮替芬的含量[J].药物分析杂志,2012,32(10):1886-1888．
【8】张晓鹏,范世华.顺序注射-化学发光法测定环境水样中痕量乐果[J].理化检验-化学分册,2014,50(11):1361-1365．
【9】FLETCHER P,ANDREW K N,CALOKERINOS A C,et al. Analytical applications of flow injection with chemiluminescence detection[J]. Luminescence,2001,16(1):1-23．
【10】余雅玲,沈宏.5-磺基水杨酸增敏-微顺序注射-化学发光法测定次氯酸盐[J].理化检验-化学分册,2013,49(12):1419-1422．
【11】NIE Fei,LU Jiu-ru. Determination of ketotifen by using calcein as chemiluminescence reagent[J]. Anal Chin Acta,2007,592(2):168-172．
【12】李利军,邓春燕,高文燕,等.卤素离子-富马酸酮替芬-联吡啶钌体系电化学发光的研究及应用[J].分析试验室,2012,31(9):21-25．
【13】WHITE E H,BURSEY M M. Chemiluminescence of luminol and related hydrazides: the light emission step[J]. J Am Chem Soc,1964,86:941-942．
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