共振散射光谱法测定卡波姆
Determination of Carbomer by Resonance Scattering Spectrometry
摘 要
基于卡波姆在强酸性介质中产生自聚集作用导致其共振散射光显著增强,建立了测定卡波姆的共振散射光谱法。在优化的试验条件下,卡波姆940,971P,974P质量浓度的线性范围分别为20~120 mg·L-1,50~300 mg·L-1,20~300 mg·L-1,检出限(3σ)分别为0.2,0.03,0.14 μg·L-1。方法用于样品分析,加标回收率在96.9%~100%之间,测定值的相对标准偏差(n=6)在1.2%~2.3%之间。
卡波姆
自聚集
Resonance scattering spectrometry
Carbomer
Self-aggregation
Abstract
A method of resonance light scattering spectroscopy was proposed for the determination of carbomer, based on the significant increases in the intensity of the resonance scattering light due to self-aggregations of carbomer in strong acid medium. Under optimized conditions, the linearity ranges of carbomer 940, 971P and 974P were 20-120 mg·L-1, 50-300 mg·L-1, and 20-300 mg·L-1, respectively, and the detection limits (3σ) were 0.2, 0.03, 0.14 μg· L-1, respectively. The method was used to analyze samples, giving recovery rates in the range of 96.9%-100%, and RSD (n=6) in the range of 1.2%-2.3%.
中图分类号 O657.3 DOI 10.11973/lhjy-hx201509019
所属栏目 工作简报
基金项目 广东省自然科学基金资助项目(5002841)
收稿日期 2014/8/11
修改稿日期
网络出版日期
作者单位点击查看
联系人作者叶秀金(fuhaiwu@163.com)
备注叶秀金(1985-),女,广东人,硕士研究生,研究方向 为现代分析技术在药物分析中的应用。
引用该论文: YE Xiu-jin,LI Jun-jian,SONG Fen-yun. Determination of Carbomer by Resonance Scattering Spectrometry[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2015, 51(9): 1286～1289
叶秀金,李俊健,宋粉云. 共振散射光谱法测定卡波姆[J]. 理化检验－化学分册, 2015, 51(9): 1286～1289
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参考文献
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【2】邾枝花,刘丽,季婷婷.芙蓉膏凝胶剂制备工艺［J］.中国医院药学杂志, 2010,30(8):704-705.
【3】BRON A J, MANGAT H, QUINLAN M, et al. Polyacrylic acid gel in patients with dry eyes: a randomized comparison with polyvinyl alcohol［J］. Eur J Ophthalmol, 1998,8(2):81-81.
【4】CEULEMANS J, LUDWIG A. Optimisation of carbomer viscous eye drops:an in vitro experimental design approach using rheological techniques［J］. Eur J Pharm Biopharm, 2002,54(1):41-50.
【5】刘荣,冯端浩,邓夕军,等.卡波姆助悬氢氧化铝凝胶的研制［J］.中国药学杂志, 1998,33(3):187-188.
【6】刘文静,魏玉辉,宋玉琴,等.尼古丁缓释贴剂的制备及体外透皮释药评价［J］.中国新药杂志, 2009,18(8):755-759.
【7】R.C.罗,P.J.舍斯基,P.J.韦勒.药用辅料手册［M］.4版.郑俊民译.北京:化学工业出版社, 2004.
【8】国家药典委员会.中华人民共和国药典(二部)［M］.北京:中国医药科技出版社, 2010.
【9】ZHANG Shu-hong, FAN Yong-shan, FENG Shou, et al. Microdetermination of proteins by resonance light scattering technique based on aggregation of ferric nanoparticles［J］. Spectrochim Acta A, 2009,72(4):748-752.
【10】钱纯.镍(Ⅱ)-1-(2-吡啶偶氮)-2-萘酚-十二烷基苯磺酸钠体系共振光散射法测定痕量镍［J］.理化检验-化学分册, 2009,45(4):431-433.
【11】朱乾华,万帮江,张敏,等.赤藓红共振瑞利散射光谱法测定盐酸多塞平［J］.理化检验-化学分册, 2012,48(10):1158-1163.
【12】CHEN Zhan-guang, ZHU Li, SONG Tian-he, et al. Determination of dextrin based on its self- aggregation by resonance light scattering technique［J］. Anal Chim Acta, 2009,635:202-206.
【13】王彦,王子娟.卡波姆在药剂学中的应用［J］.中国药事, 2005,19(6):361-365.
【14】苏杰,张钧寿,吴葆金,等.卡波姆-新型药物辅料［J］.中国药学杂志, 2000,35(9):579-581.
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