GC-MS测定人血清中酞酸酯类环境污染物
GC/MS DETERMINATION OF PHTHALATES IN HUMAN SERUM
摘 要
为了解酞酸酯类环境污染物在人血清中的含量水平.采用毛细管柱气相色谱-质谱联用法的选择离子检测(GC-MS-SIR)技术,结合有机溶剂提取,高速离心去蛋白和低温浓缩的方法测定103份健康人血清中酞酸二丁酯(di-n-butyl phthalate,DBP)和酞酸二异辛酯[di-(2-ethylhexyl) phthalate,DEHP].测定结果提示酞酸酯类环境污染物已进入人血清,DBP约为7.10 mg·L-1,DEHP约为6.78 mg·L-1,大部分人体内已有一定的污染负荷.
酞酸酯
选择离子检测
血清
GC/MS
Phthalates
Selected ion recording
Human serum
Abstract
Selected ion recording (SIR) technique was used in the GC/MS determination of phthalates (DBP and DEHP),present as environmental pollutants in human serum.The serum samples,taken from 103 healthy persons of 49 to 66 years old,living in suburbs of shanghai,were mixed with hexane and centrifuga lized at 10 000 r·min-1 for 8 min.The upper hexane layers in 3 extractions were collected and concentrated to 2 mL.DBP and DEHP in the solution were determined by GC/MS,and their contents were found in the ranges of ND -7.10 mg·L-1 and Nd -6.78 mg·L-1 respectively.Warnings were shown by the results that definite pollution of phthalates happened in the serum samples taken.
中图分类号 O657.63
所属栏目 工作简报
基金项目 国家自然科学基金资助项目(30271123)
收稿日期 2005/1/11
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备注蔡智鸣(1949-),男,江苏南京人,副教授,从事环境和食品卫生学研究.
引用该论文: CAI Zhi-ming,SHI Xin,ZHANG Qian-long,WANG Feng-hua,ZENG Ying,ZHANG Jun-yong,LI Shu-guang. GC/MS DETERMINATION OF PHTHALATES IN HUMAN SERUM[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2006, 42(2): 115～117
蔡智鸣,史馨,张前龙,王枫华,曾盈,张俊勇,厉曙光. GC-MS测定人血清中酞酸酯类环境污染物[J]. 理化检验－化学分册, 2006, 42(2): 115～117
被引情况:
【1】张丽丽,陈焕文,李建强,吴转璋,郇延富, "邻苯二甲酸酯类化合物检测方法研究进展",理化检验－化学分册 47, 241-247(2011)
【2】苏晓,王修鹏,王岩, "气相色谱-质谱法测定食品中邻苯二甲酸酯",理化检验－化学分册 48, 823-827(2012)
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参考文献
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【2】WHO/IPCS.Environmental Health Criteria 189,Di-n-Butyl Phthalate[M].Geneva: World Health Organization,1997.
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【4】蔡智鸣,张前龙,赵文红,等.色谱质谱测定塑料食品袋溶出的酞酸酯DBP与DEHP[J].理化检验-化学分册,2003,39(9):529-534.
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【9】GB 3838-2002,集中式生活饮用水地表水源地特定项目标准限量值[S].
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【2】WHO/IPCS.Environmental Health Criteria 189,Di-n-Butyl Phthalate[M].Geneva: World Health Organization,1997.
【3】Doull J,Casttley R,Elcombe C,et al.A Cancer Risk Assessment of Di (2-Ethylthexyl) Phthalate: Application of the New U.S.EPA Risk Assessment Guidelines[J].Tocicol Pharm,1999,29(3):327-357.
【4】蔡智鸣,张前龙,赵文红,等.色谱质谱测定塑料食品袋溶出的酞酸酯DBP与DEHP[J].理化检验-化学分册,2003,39(9):529-534.
【5】汪多仁.增塑剂化学品生产配方和合成工艺[M].北京:科学技术文献出版社,1999.112-115.
【6】WHO/IPCS.Global Assessment of the State-of-the-Science of Endocrine Disruptors[M].Geneva: World Health Organization,2002.
【7】邓茂先,陈祥贵.环境内分泌干扰物研究进展[J].国外医学卫生学分册,2000,27(2):65-68.
【8】国家环保局科技发展计划科研结果评定报告.潜在有毒化学品优先控制方法研究[M].北京:中国环境科学研究院,1992.116-122.
【9】GB 3838-2002,集中式生活饮用水地表水源地特定项目标准限量值[S].
【10】陈学敏,吴德生.环境卫生学.第四版[M].北京:人民卫生出版社,2001.340-342.
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