利眠宁的二阶导数单扫描示波极谱测定及其电化学行为
Second Derivative Single-Sweeping Oscillopolarographic Determination of Chlordiazepoxide and Its Electrochemical Behavior
摘 要
提出了测定药物利眠宁的二阶导数单扫描示波极谱方法.在 0.12 mol·L-1氨水-NH4Cl (pH 10.2±0.1)的缓冲溶液中,利眠宁于-1.25 V处产生一极谱还原波,二阶导数峰电流与其浓度在1.6×10-7~2.4×10-5mol·L-1范围内呈线性关系(r=0.999 3,n=8),检出限为2.0×10-8mol·L-1.测定了片剂中利眠宁的含量.测得结果与HPLC法的结果一致,其RSD值为0.56%,回收率结果在96.4%~102.1%之间,讨论了利眠宁的电化学行为.
单扫描示波极谱法
电化学行为
Single-sweeping oscillopolarography
Chlordiazepoxide
Electrochemical behavior
Abstract
Single-sweeping oscillopolarography was applied to the determination of chlordiazepoxide. A polarographic reductive wave of chlordiazepoxide was observed at -1.25 V in an ammoniacal buffer medium of pH 10.2±0.1. Linearity was kept between the 2nd derivative of peak current (I″p) and the concentration of chlordiazepoxide and in the range of 1.6×10-7-2.4×10-5mol·L-1 (r=0.999 3,n=8),with a detection limit of 2.0×10-8mol·L-1. In its application to the analysis of chlordiazepoxide tablets,results obtained were in consistency with the results found by HPLC. Value of RSD′s (n=8) of this method was found to be 0.56%. Recovery test was performed and results obtained were in the range of 96.4%-102.1%. A study on the electrochemical behavior of chlordiazepoxide was also made and a brief discussion was given.
中图分类号 O657.1
所属栏目 工作简报
基金项目
收稿日期 2006/1/30
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备注林洪(1971-),男,云南玉溪市人,副教授,硕士,研究方向为电分析化学.
引用该论文: LIN Hong,LI Ming,LI De-liang,AI Hua-lin,CAI Yao-dong. Second Derivative Single-Sweeping Oscillopolarographic Determination of Chlordiazepoxide and Its Electrochemical Behavior[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2007, 43(7): 585～587
林洪,李明,李德良,艾华林,柴跃东. 利眠宁的二阶导数单扫描示波极谱测定及其电化学行为[J]. 理化检验－化学分册, 2007, 43(7): 585～587
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参考文献
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【3】Qiu F H,Liu L. Determination of basic drugs in blood by GC-FID with solid-phase extn[J]. Acta Pharm Sci,1996,31(4):296-299．
【4】钟爱国.利眠宁汞修饰碳糊电极的制作及应用[J].分析科学学报,2003,19(6):590-591．
【5】Oelschlager H. Polarographic behavior of chlordiazepoxide[J]. Arch Pharm,1963,296(4):396-403．
【6】Oelschlager H,Hoffmann H. Analysis of drugs by polarography(Ⅶ): mechanism of polarographic reduction of chlordiazepoxide[J]. Arch Pharm,1967,300(3):250-257．
【7】Lorenzo E,Hernandez L. Adsorptive stripping voltammetry of chlordiazepoxide at the hanging mercury drop electrode[J]. Anal Chim Acta,1987,201(2):275-280．
【8】Sreedhar N Y,Raddy S J. Determination of chlordiazepoxide in pharmaceutical formulation by polarography[J]. Orient J Chem,1991,7(4):191-197．
【9】张祖训,屠一峰.二阶导数线性变位示波极谱研究[J].高等学校化学学报,1985,6(5):404-408．
【10】Laviron E. Adsorotion autoinhibition and autocatalysis in polarography and in linear potential sweep voltammetry[J]. J Electroanal Chem,1974,52(7):355-360．
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