电荷转移分光光度法测定阿莫西林
Charge Transfer-Spectrophotometric Determination of Amoxicillin
摘 要
阿莫西林与对苯醌在pH 5.8~6.2的乙酸-乙酸钠缓冲溶液中形成1∶1荷移络合物,其最大吸收波长为476 nm,表观摩尔吸光率为2.0×103L·mol-1·cm-1,阿莫西林质量浓度在200 mg·L-1以内服从比耳定律.用此方法测定药物制剂中阿莫西林的含量,结果与药典方法一致.相对标准偏差(n=6)均小于1.5%.
电荷转移反应
阿莫西林
对苯醌
Spectrophotometry
Charge transfer reaction
Amoxicillin
p-Benzoquinone
Abstract
In an acetate buffer medium of pH 5.8-6.2,a charge transfer complex with molar composition ratio of 1 to 1 was formed between amoxicillin (AMXL) and p-benzoquinone,with its absorption maximum at 476 nm and molar absorptivity of 2.0×103L·mol-1·cm-1.Beer′s law was kept in the concentration range of AMXL within 200 mg·L-1.The proposed method was used in the analysis of AMXL preparations,giving results in consistency with the results obtained by the pharmacopia method.Values of RSD′s (n=6) obtained by this method were less than 1.5%.
中图分类号 O657.31
所属栏目 工作简报
基金项目
收稿日期 2006/12/16
修改稿日期
网络出版日期
作者单位点击查看
备注曹伟(1962-),男,山东长清人,教授,主要研究方向为分子光谱分析.
引用该论文: CAO Wei,FU Yan-jing,MA Yan,MU Xue-min,YANG Jing-he. Charge Transfer-Spectrophotometric Determination of Amoxicillin[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2008, 44(4): 334～335
曹伟,傅艳静,马艳,牟学敏,杨景和. 电荷转移分光光度法测定阿莫西林[J]. 理化检验－化学分册, 2008, 44(4): 334～335
共有人对该论文发表了看法，其中：
人认为该论文很差
人认为该论文较差
人认为该论文一般
人认为该论文较好
人认为该论文很好
参考文献
【1】李媛,郎惠云,李会娥,等.流动注射在线过滤稀释-原子吸收分光光度法测定阿莫西林[J].分析化学,2000,28(10):1252-1255．
【2】Bobrowska-Grzasik E.Determination of amoxycillin and clavulamic acid in some pharmaceutical preparations by derivative spectrophotometry[J].Mikrochim Acta,2001,136(1/2):31-34．
【3】李华侃,鄂义峰,陈连山,等.羟氨苄青霉素干糖浆中有效成分的测定[J].分析化学,1999,27(3):370．
【4】Ruiz Medina A,Fernandez de Cordora M L,Molina Diaz A.Flow-through solid phase UV spectrophotometric determination of amoxycillin[J].Anal Lett,1999,32(4):729-742．
【5】Saadia M El-Ashry,Fathalla Belal,Mohamed M El-Kerdawy,et al.Spectrophotometric determination of some phenolic antibiotics in dosage forms[J].Mikrochim Acta,2000,135(3/4):191-196．
【6】Muiioz de la Peiia A,Acedo-Valenzuela M I,Espinosa-Mansilla A,et al.Stopped-flow fluorimetric determination of amoxycillin and clavulamic acid by partial least-squares multivariate calibration[J].Talanta,2002,56(4):635-642．
【7】Yang J,Zhou G,Cao X,et al.Study on the fluorescence characteristics of alkaline degradation of cefadroxil,cephradine,cefotaximum sodium and amoxicillin[J].Anal Lett,1998,31(6):1047-1060．
【8】中华人民共和国药典编委会.中华人民共和国药典(二部)[M].北京:化学工业出版社,2000:338-339．
【9】Cass Q B,Gomes R F,Calafatti S A,et al.Determination of amoxicillin in human plasma by direct injection and coupled column high-performance liquid chromatography[J].Journal of Chromatography A,2003,987:235-241．
【10】Aghazadeh A,Kazemifard G.Simultaneous determination of amoxycillin and clavulanic acid in pharmaceutical dosage forms by LC with amperometric detection[J].J Pharm Biomed Anal,2001,25:325-329．
【11】Du J X,Li Y H,Lu J R.Chemiluminescence flow injection analysis of amoxycillin by a permanganate-based reaction[J].Anal Lett,2002,35(14):2295-2304．
【12】Cao Wei,Yang Jinghe,Sun Changxia,et al.Flow injection-chemiluminescence determination of amoxicillin using potassium permanganate and formaldehyde system[J].Luminescence,2005,20(1):20-24．
【13】李华侃,赵凤林,童沈阳.荷移反应用于氨苄青霉素的测定[J].分析化学,1997,25(1):46-48．
【2】Bobrowska-Grzasik E.Determination of amoxycillin and clavulamic acid in some pharmaceutical preparations by derivative spectrophotometry[J].Mikrochim Acta,2001,136(1/2):31-34．
【3】李华侃,鄂义峰,陈连山,等.羟氨苄青霉素干糖浆中有效成分的测定[J].分析化学,1999,27(3):370．
【4】Ruiz Medina A,Fernandez de Cordora M L,Molina Diaz A.Flow-through solid phase UV spectrophotometric determination of amoxycillin[J].Anal Lett,1999,32(4):729-742．
【5】Saadia M El-Ashry,Fathalla Belal,Mohamed M El-Kerdawy,et al.Spectrophotometric determination of some phenolic antibiotics in dosage forms[J].Mikrochim Acta,2000,135(3/4):191-196．
【6】Muiioz de la Peiia A,Acedo-Valenzuela M I,Espinosa-Mansilla A,et al.Stopped-flow fluorimetric determination of amoxycillin and clavulamic acid by partial least-squares multivariate calibration[J].Talanta,2002,56(4):635-642．
【7】Yang J,Zhou G,Cao X,et al.Study on the fluorescence characteristics of alkaline degradation of cefadroxil,cephradine,cefotaximum sodium and amoxicillin[J].Anal Lett,1998,31(6):1047-1060．
【8】中华人民共和国药典编委会.中华人民共和国药典(二部)[M].北京:化学工业出版社,2000:338-339．
【9】Cass Q B,Gomes R F,Calafatti S A,et al.Determination of amoxicillin in human plasma by direct injection and coupled column high-performance liquid chromatography[J].Journal of Chromatography A,2003,987:235-241．
【10】Aghazadeh A,Kazemifard G.Simultaneous determination of amoxycillin and clavulanic acid in pharmaceutical dosage forms by LC with amperometric detection[J].J Pharm Biomed Anal,2001,25:325-329．
【11】Du J X,Li Y H,Lu J R.Chemiluminescence flow injection analysis of amoxycillin by a permanganate-based reaction[J].Anal Lett,2002,35(14):2295-2304．
【12】Cao Wei,Yang Jinghe,Sun Changxia,et al.Flow injection-chemiluminescence determination of amoxicillin using potassium permanganate and formaldehyde system[J].Luminescence,2005,20(1):20-24．
【13】李华侃,赵凤林,童沈阳.荷移反应用于氨苄青霉素的测定[J].分析化学,1997,25(1):46-48．
相关信息
