咖啡酸分子印迹聚合物的制备及其用于咖啡酸的高效液相色谱分离
Preparation of Caffeic Acid Molecularly Imprinted Polymer and Its Application to Separation of Caffeic Acid by HPLC
摘 要
以咖啡酸为模板分子,丙烯酰胺为功能单体,在水溶液中合成了咖啡酸分子印迹聚合物,制备了分子印迹聚合物色谱分离柱.试验结果表明:聚合物对印迹分子具有很好的亲和性和特异选择性,以甲醇-水(25+75)混合溶液为流动相,咖啡酸与其相似物绿原酸的分离度达到1.91.
分子印迹
功能单体
高效液相色谱
Caffeic acid
Molecular imprinting
Functional monomer
HPLC
Abstract
The molecularly imprinted polymer (MIP) of caffeic acid was synthesized in aqueous medium with caffeic acid as template molecule and acrylamide as functional monomer,and it was used to prepared chromatographic column.It was found that the imprinted polymer had good affinity and marked selectivity for caffeic acid.A mixed solution of methanol-water (25+75) was used as mobile phase,the resolution of caffeic acid with its analogue caffetannic acid achieved to 1.91.
中图分类号 O652.63
所属栏目 工作简报
基金项目 黑龙江省教育厅(11511435);齐齐哈尔市工业攻关项目(GG06-19)
收稿日期 2009/4/25
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备注苏立强(1962-),女,山东曲阜人,教授,从事色谱理论与应用研究.
引用该论文: SU Li-qiang,LIANG Yun-kai,ZHANG Xiao-lin. Preparation of Caffeic Acid Molecularly Imprinted Polymer and Its Application to Separation of Caffeic Acid by HPLC[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2010, 46(6): 677～679
苏立强,梁云凯,张晓林. 咖啡酸分子印迹聚合物的制备及其用于咖啡酸的高效液相色谱分离[J]. 理化检验－化学分册, 2010, 46(6): 677～679
被引情况:
【1】苏立强,郭晓丽,栾田, "沉淀聚合法制备莱克多巴胺分子印迹聚合物",理化检验－化学分册 49, 256-259(2013)
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参考文献
【1】LIU Mei,LU Jiu-ru,HE Yun-hua,et al.Molecular imprinting-chemiluminescence sensor for the determination of brucine[J].Anal Chim Acta,2005,541:97-102．
【2】PESTOV D,LEVIT N,MANISCALCO V,et al.Molecular imprinting using monomers with solid-state polymerization[J].Anal Chim Acta,2004,504:31-35．
【3】GOMY C,SCHMITZER A R.Synthesis and photoresponsive properties of a molecularly imprinted polymer[J].Organic Letters,2007,9(20):3865-3868．
【4】WEI Xiao-lin,HUSSON S M,Surface-Grafted.Molecularly imprinted polymers grown from silica gel for chromatographic separations[J].Ind Eng Chem Res,2007,46(7):2117-2124．
【5】HALL A J,SELLERGREN F L,MANESIOTIS P,et al.Non-covalent imprinting of phosphorous esters[J].Anal Chim Acta,2005,540:9-14．
【6】王学军,许振良,杨座国,等.水相识别分子印迹技术[J].化学进展,2007,19(5):805-812．
【7】RACHKOV A,HU M J,BULGAREVICH E,et al.Molecularly imprinted polymers prepared in aqueous solution selective for angiotensin II[J].Anal Chim Acta,2003,504(2004):191-197．
【8】赖家平,曹现峰,何锡文,等.水溶液中制备分子印迹聚合物微球及其分子识别特性研究[J].化学学报,2002,60(2):322-327．
【9】苏立强,王俊涛,何丹凤,等.水杨酸分子印迹分离介质的水相制备及色谱行为[J].化学通报,2006,69(3):216-219．
【2】PESTOV D,LEVIT N,MANISCALCO V,et al.Molecular imprinting using monomers with solid-state polymerization[J].Anal Chim Acta,2004,504:31-35．
【3】GOMY C,SCHMITZER A R.Synthesis and photoresponsive properties of a molecularly imprinted polymer[J].Organic Letters,2007,9(20):3865-3868．
【4】WEI Xiao-lin,HUSSON S M,Surface-Grafted.Molecularly imprinted polymers grown from silica gel for chromatographic separations[J].Ind Eng Chem Res,2007,46(7):2117-2124．
【5】HALL A J,SELLERGREN F L,MANESIOTIS P,et al.Non-covalent imprinting of phosphorous esters[J].Anal Chim Acta,2005,540:9-14．
【6】王学军,许振良,杨座国,等.水相识别分子印迹技术[J].化学进展,2007,19(5):805-812．
【7】RACHKOV A,HU M J,BULGAREVICH E,et al.Molecularly imprinted polymers prepared in aqueous solution selective for angiotensin II[J].Anal Chim Acta,2003,504(2004):191-197．
【8】赖家平,曹现峰,何锡文,等.水溶液中制备分子印迹聚合物微球及其分子识别特性研究[J].化学学报,2002,60(2):322-327．
【9】苏立强,王俊涛,何丹凤,等.水杨酸分子印迹分离介质的水相制备及色谱行为[J].化学通报,2006,69(3):216-219．
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