Photometric Determination of Famotidine by Its Change-Transfer Reaction with Alizarin Red
摘 要
采用分光光度法研究了法莫替丁和茜素红的荷移反应,建立了荷移分光光度法测定法莫替丁的方法.在水溶液中,法莫替丁和茜素红形成的络合物的最大吸收波长为525 nm,两者的组成比为1比1.法莫替丁质量浓度在8.0~142.0 mg·L-1范围内符合比耳定律.采用此方法分别测定了法莫替丁片剂和胶囊中法莫替丁含量,所得测定值与标示值相符.用标准加入法作方法的回收和精密度试验,测得回收率为100.8%(片剂)和99.6%(胶囊),测定值的相对标准偏差(n=7)依次为1.01%及0.56%.
Abstract
As studied by photometry,a complex with composition ratio of 1 to 1 was formed by the charge-transfer reaction between famotidine and alizarin red,having its absorption maximum at the wavelength of 525 nm.Linear relationship between values of absorbance and mass concentration of farmotidine was obtained in the range from 8.0 to 142.0 mg·L-1.Based on these facts,a method of photometric determination of famotidine was proposed and used in the analysis of drug samples of famotidine tablets and capsules for their famotidine contents,giving results in consistency with the labelled values.Tests for recovery were performed by standard addition method using these drug samples as matrixes.Values of average recovery found were 100.8% for the tablets and 99.6% for the capsules.The RSD′s (n=7) calculated from the measured values were 1.01% and 0.56% respectively.
中图分类号 O657.32
所属栏目 工作简报
基金项目 江苏省高校自然科学研究计划课题(05KJB15003);淮海工学院自然科学校内课题(Z2008025)资助
收稿日期 2009/6/28
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备注刘英红(1978- ),女,吉林人,硕士,讲师,主要研究方向为光度分析和电化学分析.
引用该论文: LIU Ying-hong,SONG Qian,MA Wei-xing. Photometric Determination of Famotidine by Its Change-Transfer Reaction with Alizarin Red[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2010, 46(9): 1023~1024
刘英红,宋倩,马卫兴. 基于茜素红的荷移反应光度法测定法莫替丁[J]. 理化检验-化学分册, 2010, 46(9): 1023~1024
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参考文献
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【3】李森.用电势法测定制剂中的法莫替丁[J].国外医学药学分册,1998(5):15-16.
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【6】白小红,吴冬宏.法莫替丁与氯醌酸电荷转移反应中超分子作用及其应用[J].中国医院药学杂志,2007,27(4):448-449.
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【8】刘海津,牛建平,李全民,等.阿奇霉素和茜素在甲醇中的荷移反应[J].理化检验-化学分册,2005,41(10):759-760.
【9】赵辉,李占灵.荷移分光光度法研究进展[J].化学试剂,2008,30(9):657-658.
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