实时直接分析离子源-飞行时间质谱法快速筛查安非他明类物质
Rapid Screening of Amphetamines by Time-of-Flight Mass Spectrometry Coupled with Direct Analysis in Real Time Ion Source
摘 要
采用实时直接分析(DART)离子源结合飞行时间质谱法(TOF-MS),提出了一种快速筛查毒品检材中安非他明类物质的方法。DART离子源温度400 ℃,栅极电压200 V,进样速率0.4 mm·s-1。飞行时间质谱中选择正离子模式,孔1电压为30 V和60 V,分析8种安非他明类物质。通过得到的具有精确相对分子质量的准分子离子峰和两个以上的碎片离子峰建立筛查数据库,对检材中的安非他明类物质进行快速定性分析。8种安非他明类物质的检出限在0.05~0.1 mg·L-1之间。并分析了8种安非他明类物质在DART离子源下的裂解规律。
飞行时间质谱法
安非他明类物质
快速筛查
Direct analysis in real time
Time-of-flight mass spectrometry
Amphetamin
Rapid screening
Abstract
A method for rapid screening of 8 amphetamines in drug samples was developed based on time of flight mass spectrometry (TOF-MS) coupled with direct analysis in real time (DART) ion source. Ion source temperature of 400 ℃, grid voltage of 200 V and the injection rate of 0.4 mm·s-1 were adopted in DART, and positive ion mode and orificel voltages of 30, 60 V were adopted in TOF-MS for analysis of the 8 amphetamines. A screening database of accurate relative molecular mass of informative precursor ions and fragment ions was established for the rapid qualitative analysis of the 8 amphetamines in drug samples. The detection limits of the 8 amphetamines ranged from 0.05 to 0.1 mg·L-1. The fragmentation regularity of the 8 amphetamines in DART ion source was analysized.
中图分类号 O657.63 DOI 10.11973/lhjy-hx201601001
所属栏目 试验与研究
基金项目 上海市科学技术委员会国内合作项目 (13595810400)
收稿日期 2015/1/9
修改稿日期
网络出版日期
作者单位点击查看
备注连茹(1989-),女,河南郑州人,硕士研究生,主要 从事仪器分析和毒品毒物分析与快速检测方面的科研工作。
引用该论文: LIAN Ru,WU Zhong-ping,LV Xiao-bao,WANG Rong,NI Chun-fang,ZHANG Yu-rong. Rapid Screening of Amphetamines by Time-of-Flight Mass Spectrometry Coupled with Direct Analysis in Real Time Ion Source[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2016, 52(1): 1～6
连茹,吴忠平,吕小宝,汪蓉,倪春芳,张玉荣. 实时直接分析离子源-飞行时间质谱法快速筛查安非他明类物质[J]. 理化检验－化学分册, 2016, 52(1): 1～6
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参考文献
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【2】贾滨,徐国宾,吕小宝,等.质谱新技术在毒品分析中的应用［J］.生命科学仪器, 2014(4):7-10.
【3】WU Meng-xi, WANG Hao-yang, DONG Guo-qing, et al. Combination of solid-phase micro-extraction and direct analysis in real time-fourier transform ion cyclotron resonance mass spectrometry for sensitive and rapid analysis of 15 phthalate plasticizers in beverages［J］. Chin J Chem, 2015,33(2):213-219.
【4】LESIAK A D, SHEPARD J R. Recent advances in forensic drug analysis by DART-MS［J］. Bioanalysis, 2014,6(6):819-842.
【5】KERN S E, LIN L A, FRICKE F L. Accurate mass fragment library for rapid analysis of pesticides on produce using ambient pressure desorption ionization with high-resolution mass spectrometry［J］. Journal of the American Society for Mass Spectrometry, 2014,25(8):1482-1488.
【6】LESIAK A D, MUSAH R A, CODY R B, et al. Direct analysis in real time mass spectrometry (DART-MS) of “bath salt” cathinone drug mixtures［J］. The Analyst, 2013,138(12):3424-3432.
【7】廖杰,刘娜,刘春胜.DART-质谱及其在药物分析中的应用［J］.药物分析杂志, 2011(10):2008-2012.
【8】祁婉舒,张立,郭寅龙.实时直接分析质谱法快速鉴别天然驱蚊产品中的人工添加剂［J］.有机化学, 2013,33(2):359-364.
【9】LI Xian-jiang, XING Jia-wei, CHANG Cui-lan, et al. Solid-phase extraction with the metal-organic framework MIL-101(Cr) combined with direct analysis in real time mass spectrometry for the fast analysis of triazine herbicides［J］. Journal of Separation Science, 2014,37(12):1489-1495.
【10】吕小宝,连茹,王长亮,等.DART-TOFMS检验红色印油初探［J］.中国司法鉴定, 2015(3):65-67.
【11】吕小宝,连茹,戴维,等.主成分分析用于实时直接分析飞行时间质谱法判定中性笔字迹的形成时间［J］.理化检验-化学分册, 2015,51(5):577-580.
【12】LAPOINTE J, MUSSELMAN B, O′NEILL T, et al. Detection of “bath salt” synthetic cathinones and metabolites in urine via DART-MS and solid phase microextraction［J］. Journal of the American Society for Mass Spectrometry, 2015,26(1):159-165.
【13】MUSAH R A, CODY R B, DOMIN M A, et al. DART-MS in-source collision induced dissociation and high mass accuracy for new psychoactive substance determinations［J］. Forensic Science International, 2013(244):42-49.
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