取经前处理后的沉积物样品（5.000 g）与中性氧化铝粉25 g充分混匀，按规定条件用丙酮-甲醇（1+1）混合液进行加速溶剂萃取其中的8种内分泌干扰物。所得萃取液吹氮浓缩至2 mL，加水400 mL并调节pH至3，溶液经HLB固相萃取小柱净化。小柱用氮气吹干后，用丙酮8 mL洗脱。洗脱液经处理后进行超高效液相色谱-串联质谱分离。以BEH C₁₈柱为固定相，以不同体积比的甲醇和0.1%（体积分数）氨水溶液为流动相进行梯度洗脱。在质谱分析中，采用电喷雾负离子源和多反应监测模式。8种化合物的质量浓度在2.0~100.0 μg·L^-1范围内呈线性，检出限（3s）在0.03~0.05 μg·kg^-1之间。按标准加入法在3个浓度水平上进行回收试验，回收率在62.8%~104%之间，测定值的相对标准偏差（n=6）在2.8%~15%之间。

The pretreated sediment sample (5.000 g) was mixed thoroughly with neutral Al₂O₃ (25 g), and 8 endocrine disrupters in the sample were separated by ASE as described with a mixture of acetone and methanol (1+1). The extract was concentrated to 2 mL by N₂-blowing, 400 mL of water were added and acidity of the solution was adjusted to pH 3. The solution was then purified by passing through HLB-SPE column. After drying the column by N₂-blowing, it was eluted with 8 mL of acetone. The treated eluate was separated by UHPLC using BEH C₁₈ column as the stationary phase, and mixtures of methanol and 0.1% (φ) ammonia solution, mixed in various volumic ratios, as mobile phase in gradient elution. ESI^- and MRM were adopted in MS. Linear relationships between values of peak area and mass concentration of 8 compounds were found in the range of 2.0-100.0 μg·L^-1, with detection limits (3s) in the range of 0.03-0.05 μg·kg^-1. Test for recovery was made by standard addition method at 3 concentration levels, giving results in the range of 62.8%-104%, with RSDs (n=6) ranged from 2.8% to 15%.