水产品样品（5.00 g）经乙腈-甲酸（99+1）混合液20 mL提取，无水乙醇除水，浓缩并加正己烷2 mL脱脂。所得溶液进行液相色谱分离。以ACQUITY UPLC BEH HILIC色谱柱为分离柱，以不同体积比的甲醇和0.1%（体积分数）甲酸溶液的混合液为流动相进行梯度洗脱。质谱分析中，采用电喷雾正离子源多反应监测模式检测。采用内标法定量。所涉11种药物的线性范围均为5~200 μg·L^-1，方法的测定下限（10S/N）在0.07~0.20 μg·kg^-1之间。在1.0，4.0，20.0 μg·kg^-1等3个浓度水平进行加标回收试验，回收率在80.3%~119%之间，测定值的相对标准偏差（n=6）在1.3%~12%之间。

The sample of aquatic products (5.00 g) was extracted with 20 mL of a mixture of acetonitrile and formic acid (99+1). The extract was dehydrated with absolute ethanol. The extract was then concentrated and 2 mL of n-hexane was added to remove fat. LC separation was performed by using ACQUITY UPLC BEH HILIC chromatographic column as stationary phase, and mixtures of methanol and 0.1% (φ) formic acid solution with various ratios as mobile phase in gradient elution. ESI⁺ and multi-reaction-monitoring were adopted in MS/MS. Internal standard method was used for quantification. Linearity ranges of the 11 drugs were found in the same range of 5-200 μg·L^-1, with lower limits of determination (10S/N) in the range of 0.07-0.20 μg·kg^-1. Tests for recovery were made by standard addition method at 3 concentration levels of 1.0, 4.0, 20.0 μg·kg^-1, giving values of recovery and RSD's (n=6) in the ranges of 80.3%-119% and 1.3%-12% respectively.