采用液相色谱-串联质谱法测定植物样品中6种合成大麻素的含量。植物样品20 mg经甲醇50 mL超声提取30 min，离心后取上清液，以C₁₈色谱柱为分离柱，以不同体积比的甲醇和水混合液为流动相进行梯度洗脱，采用电喷雾正离子源多反应监测模式检测。6种合成大麻素的质量浓度均在一定范围内与其对应的峰面积呈线性关系，方法的检出限（3S/N）为0.2~3.0 μg·L^-1。加标回收率为95.9%~104%，测定值的日内相对标准偏差（n=5）均小于6.5%，日间相对标准偏差（n=5）均小于8.0%。

LC-MS/MS was applied to the determination of 6 synthetic cannabinoids in plant sample. The plant sample (20 mg) was extracted ultrasonically with 50 mL of methanol for 30 min. After centrifugation, the supernatant obtained were used for LC-MS/MS determination. C₁₈ chromatographic column was used as stationary phase, and the mixture of methanol and water mixed in different ratios was used as mobile phase in gradient elution. ESI⁺ and multi-reactions monitor mode were adopted in MS/MS. Linear relationships between values of peak area and mass concentration of the 6 synthetic cannabinoids were kept in definite ranges, with detection limits (3S/N) in the range of 0.2-3.0 μg·L^-1. Values of recovery found by standard addition method were in the range of 95.9%-104%, values of intra-day RSD's (n=5) less than 6.5% and inter-day RSD's (n=5) less than 8.0%.