移取江水样500 mL，加入50.0 μg·L^-1内标混合溶液100 μL，采用全自动固相萃取仪（装有ENVI^TM-18固相萃取柱）进行富集净化，收集洗脱液，于40℃水浴氮吹至近干，用乙腈（1+1）溶液定容至1.0 mL，采用超高效液相色谱-串联质谱法同时测定其中8种酚类内分泌干扰物的含量。以HSS T3色谱柱为固定相，以不同体积比的0.1%（质量分数）氨水和乙腈的混合液为流动相进行梯度洗脱，串联质谱分析中采用电喷雾负离子源和多反应监测模式。采用内标法定量，8种酚类内分泌干扰物的线性范围均为0.10~40.00 μg·L^-1，检出限（3S/N）为0.008~0.096 ng·L^-1。方法用于闽江水样的分析，加标回收率为80.0%~91.8%，回收量的相对标准偏差（n=6）为2.9%~12%。

The river water sample (500 mL) was collected and 50.0 μg·L^-1 mixed solution of internal standard (100 μL) were added. Enrichment and purification were processed by the instrument of automated solid phase extraction with ENVI^TM-18 solid phase extraction column. The collected eluate was evaporated to near dryness by N₂-blowing at 40℃ in the water bath and then made up to 1.0 mL with acetonitrile (1+1) solution. UHPLC-MS/MS was applied to the simultaneous determination of 8 phenolic endocrine disrupting chemicals in the solution. HSS T3 chromatographic column was used as stationary phase, and the mixture of 0.1% (mass fraction) ammonia and acetonitrile mixed in different ratios was used as mobile phase in gradient elution. ESI^- and multi-reactions monitor mode were adopted in MS/MS. Internal standard method was used for quantitative.Linearity ranges of the 8 phenolic endocrine disrupting chemicals were found in the same range of 0.10-40.00 μg·L^-1 with detection limits (3S/N) in the range of 0.008-0.096 ng·L^-1. The proposed method was applied to the analysis of the water sample of Minjiang River, giving values of recovery found by standard addition method and RSDs (n=6) of recovery amounts in the ranges of 80.0%-91.8% and 2.9%-12% respectively.