为测定皮革制品中含氯苯酚的含量，在1.000 g皮革样品中加入1 mol·L^-1硫酸溶液20 mL，用水蒸气蒸馏出样品中的含氯苯酚，馏出液和无水碳酸钾反应，含氯苯酚全部转化为含氯苯酚钾盐，经乙酸酐乙酰化后，所得衍生产物经DB-5MS毛细管色谱柱和程序升温分离，进入质谱仪，在电子轰击（EI）离子源和选择离子监测（SIM）模式下测定，内标法定量。结果表明：19种含氯苯酚质量浓度为1~40 μg·L^-1时，其对应的乙酰化产物与内标物的乙酰化产物的质量浓度之比与相应的峰面积比呈良好的线性关系，检出限（3s）为0.006~0.015 mg·kg^-1；以空白皮革制品为基质进行3个浓度水平的加标回收试验，回收率为85.7%~105%，相对标准偏差（n=6）为2.3%~8.0%。利用此方法分析了20个皮革制品，在5个样品中检出3，5-DiCP、2，4，6-TriCP、2，3，4，6-TeCP和PCP，检出值为0.20~1.11 mg·kg^-1，共有5个检出值大于GB/T 18885-2009规定的限值（0.5 mg·kg^-1）。

To determine content of chlorophenols in leather products, 1.000 g of samples was taken and added into 20 mL of 1 mol·L^-1 sulfuric acid solution and the chlorophenols in sample were extracted by water vapor distillation. Distillate obtained was reacted with potassium carbonate, thus to have chlorophenols converted into chlorinated phenyl potassium salt. After acetylated by acetic anhydride, these accetates were separated by DB-5MS chromatographic column with programmed temperature, and then determined by MS under EI and SIM mode. An internal standard method was adopted for quantification. As shown by results, when the mass concentrition of 19 chlorophenols was in the range of 1-40 μg·L^-1, ratio of mass concentration of their acetylation products between chlorophenols and the internal standard substance was linear with their respective ratios of peak area, with detection limits (3s) in the range of 0.006-0.015 mg·kg^-1. The recovery was made on blank leather products by standard addition method at 3 concentration levels, giving recoveries ranged from 85.7% to 105%. Values of RSDs (n=6) were found in the range of 2.3%-8.0%. The prescribed method was used for determination of 20 leather products, 3,5-DiCP, 2,4,6-TriCP, 2,3,4,6-TeCP and PCP were detected in 5 samples, with detection values in the range of 0.20-1.11 mg·kg^-1 and 5 detected values over the limit value (0.5 mg·kg^-1) given by GB/T 18885-2009.