基于金属有机骨架材料的电化学DNA传感器在分析检测领域的应用进展
Application Progress of Electrochemical DNA Sensors Based on Metal-Organic Framework Materials in Analysis and Detection Field
摘 要
电化学DNA传感器是基于DNA探针与目标DNA之间碱基互补配对原则构建的传感器，根据识别元件与目标物结合前后信号变化实现目标物的检测，已成为传统检测方法的有效替代方法。而金属有机骨架材料（MOFs）具有比表面积大、孔隙率高、孔径可调和热稳定性强等诸多优点，引起学者的广泛关注，已初步用于电化学DNA传感器的构建，并用于肿瘤标志物、抗生素及重金属等的灵敏、准确检测。为此，综述了电化学DNA传感器的DNA探针固定方法及信号物质，重点介绍了基于MOFs的电化学DNA传感器在分析检测领域的应用进展，并对其未来发展方向进行了展望（引用文献50篇）。
电化学DNA传感器
分析检测
综述
metal-organic framework material
electrochemical DNA sensor
analysis and detection
review
Abstract
Electrochemical DNA sensor was a sensor constructed based on base complementary pairing rules between DNA probe and target DNA, which detected targets according to the change of signal before and after the binding of recognition elements and targets, and had become an effective alternative to traditional detection methods. Metal-organic framework materials (MOFs) had many advantages, including large specific surface area, high porosity, adjustable pore size and high thermal stability, attracting wide attention from scholars. MOFs had been initially used for the construction of electrochemical DNA sensors, which were applied to the sensitive and accurate detection of tumor markers, antibiotics and heavy metals. Therefore, the DNA probe immobilization methods and signal substances of electrochemical DNA sensors were reviewed, the application progress of electrochemical DNA sensors based on MOFs in the field of analysis and detection were focused, and its future development direction was prospected (50 ref. cited).
中图分类号 O657.1 DOI 10.11973/lhjy-hx202209021
所属栏目 专题报道(新材料分析)
基金项目 国家自然科学基金（82173568，81703269）、牡丹江医学院博士科研启动金（2021-MYBSKY-009，2021-MYBSKY-001）
收稿日期 2022/4/24
修改稿日期
网络出版日期
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备注江兰,硕士研究生,研究方向为慢性病流行病学及生物传感技术研究
引用该论文: JIANG Lan,HANG Yongzheng,ZOU Lina,PAN Hongzhi,RONG Shengzhong,MA Hongkun. Application Progress of Electrochemical DNA Sensors Based on Metal-Organic Framework Materials in Analysis and Detection Field[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2022, 58(9): 1109～1116
江兰,杭永正,邹立娜,潘洪志,荣胜忠,马宏坤. 基于金属有机骨架材料的电化学DNA传感器在分析检测领域的应用进展[J]. 理化检验－化学分册, 2022, 58(9): 1109～1116
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参考文献
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【28】YU H, HAN J, AN S J, et al. Ce(Ⅲ,Ⅳ)-MOF electrocatalyst as signal-amplifying tag for sensitive electrochemical aptasensing[J]. Biosensors and Bioelectronics, 2018,109:63-69.
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【30】WU C J, WANG S F, LUO X L, et al. Adenosine triphosphate responsive metal-organic frameworks equipped with a DNA structure lock for construction of a ratiometric SERS biosensor[J]. Chemical Communications, 2020,56(9):1413-1416.
【31】DRATWA M, WYSOCZAHSKA B, ŁACINA P, et al. TERT-regulation and roles in cancer formation[J]. Frontiers in Immunology, 2020,11:929-945.
【32】ROAKE C M, ARTANDI S E. Regulation of human telomerase in homeostasis and disease[J]. Nature Reviews Molecular Cell Biology, 2020,21(7):384-397.
【33】DONG P F, ZHU L Y, HUANG J, et al. Electrocatalysis of cerium metal-organic frameworks for ratiometric electrochemical detection of telomerase activity[J]. Biosensors and Bioelectronics, 2019,138:3-13.
【34】WANG Y Q, DONG P F, HUANG J, et al. Direct electrochemistry of silver nanoparticles-decorated metal-organic frameworks for telomerase activity sensing via allosteric activation of an aptamer hairpin[J]. Analytica Chimica Acta, 2021,1184:36-46.
【35】BAUTISTA-SÁNCHEZ D, ARRIAGA-CANON C, PEDROZA-TORRES A, et al. The promising role of miR-21 as a cancer biomarker and its importance in RNA-based therapeutics[J]. Molecular Therapy-Nucleic Acids, 2020,20:409-420.
【36】HUANG B, WU G Z, PENG C X, et al. miR-126 regulates the proliferation, migration, invasion, and apoptosis of non-small lung cancer cells via AKT2/HK2 axis[J]. IUBMB Life, 2021:1-10.
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【38】HU M, ZHU L, LI Z Z, et al. CoNi bimetallic metal-organic framework as an efficient biosensing platform for miRNA 126 detection[J]. Applied Surface Science, 2021,542:586-597.
【39】HAO C, ZHANG G Q, ZHANG L J. Serum CEA levels in 49 different types of cancer and noncancer diseases[J]. Progress in Molecular Biology and Translational Science, 2019,162:213-227.
【40】LI J F, LIU L, AI Y J, et al. Self-polymerized dopamine-decorated Au NPs and coordinated with Fe-MOF as a dual binding sites and dual signal-amplifying electrochemical aptasensor for the detection of CEA[J]. ACS Applied Materials & Interfaces, 2020,12(5):5500-5510.
【41】CHEN M, GAN N, ZHOU Y, et al. An electrochemical aptasensor for multiplex antibiotics detection based on metal ions doped nanoscale MOFs as signal tracers and RecJf exonuclease-assisted targets recycling amplification[J]. Talanta, 2016,161:867-874.
【42】WANG S Y, HE B S, LIANG Y, et al. Exonuclease III-driven dual-amplified electrochemical aptasensor based on PDDA-Gr/PtPd@Ni-Co hollow nanoboxes for chloramphenicol detection[J]. ACS Applied Materials & Interfaces, 2021,13(22):26362-26372.
【43】HE Y Q, GAO Y, GU H W, et al. Target-induced activation of DNAzyme for sensitive detection of bleomycin by using a simple MOF-modified electrode[J]. Biosensors and Bioelectronics, 2021,178:3034-3039.
【44】ZHANG X N, ZHU M C, JIANG Y J, et al. Simple electrochemical sensing for mercury ions in dairy product using optimal Cu2+-based metal-organic frameworks as signal reporting[J]. Journal of Hazardous Materials, 2020,400:222-229.
【45】YU Y J, YU C, NIU Y Z, et al. Target triggered cleavage effect of DNAzyme:Relying on Pd-Pt alloys functionalized Fe-MOFs for amplified detection of Pb2+[J]. Biosensors and Bioelectronics, 2018,101:297-303.
【46】XIE F T, ZHAO X L, CHI K N, et al. Fe-MOFs as signal probes coupling with DNA tetrahedral nanostructures for construction of ratiometric electrochemical aptasensor[J]. Analytica Chimica Acta, 2020,1135:123-131.
【47】WEN X Y, HUANG Q W, NIE D X, et al. A multifunctional N-doped Cu-MOFs (N-Cu-MOF) nanomaterial-driven electrochemical aptasensor for sensitive detection of deoxynivalenol[J]. Molecules, 2021,26(8):2243-2254.
【48】QIU W W, GAO F, YANO N, et al. Specific coordination between Zr-MOF and phosphate-terminated DNA coupled with strand displacement for the construction of reusable and ultrasensitive aptasensor[J]. Analytical Chemistry, 2020,92(16):11332-11340.
【49】DAI G, LI Z, LUO F F, et al. Simultaneous electrochemical determination of nuc and mecA genes for identification of methicillin-resistant Staphylococcus aureus using N-doped porous carbon and DNA-modified MOF[J]. Mikrochimica Acta, 2021,188(2):39-48.
【2】AYDOǦDUTIǦ G, KOYUNCU Z D, ZEYBEK B, et al. Interaction of prednisone with dsDNA at silver nanoparticles/poly(glyoxal-bis(2-hydroxyanil))/dsDNA modified electrode and its analytical application[J]. Bioelectrochemistry, 2019,126:56-63.
【3】ARYA S K, ESTRELA P. Recent advances in enhancement strategies for electrochemical ELISA-based immunoassays for cancer biomarker detection[J]. Sensors, 2018,18(7):2010-2020.
【4】LING P H, LEI J P, ZHANG L, et al. Porphyrin-encapsulated metal-organic frameworks as mimetic catalysts for electrochemical DNA sensing via allosteric switch of hairpin DNA[J]. Analytical Chemistry, 2015,87(7):3957-3963.
【5】LÜ M M, FAN S F, WANG Q L, et al. An enzyme-free electrochemical sandwich DNA assay based on the use of hybridization chain reaction and gold nanoparticles:Application to the determination of the DNA of Helicobacter pylori[J]. Mikrochimica Acta, 2019,187(1):73-83.
【6】LOW K F, ZAIN Z M, YEAN C Y. A signal-amplified electrochemical DNA biosensor incorporated with a colorimetric internal control for Vibrio cholerae detection using shelf-ready reagents[J]. Biosensors and Bioelectronics, 2017,87:256-263.
【7】GONG Q J, WANG Y D, YANG H Y. A sensitive impedimetric DNA biosensor for the determination of the HIV gene based on graphene-Nafion composite film[J]. Biosensors and Bioelectronics, 2017,89:565-569.
【8】WU X J, HAN S T, YANG Y, et al. Decreased brain GABA levels in patients with migraine without aura:An exploratory proton magnetic resonance spectroscopy study[J]. Neuroscience, 2022,488:10-19.
【9】NING W Y, DI Z H, YU Y J, et al. Imparting designer biorecognition functionality to metal-organic frameworks by a DNA-mediated surface engineering strategy[J]. Small, 2018,14(11):3812-3820.
【10】EVTUGYN G, BELYAKOVA S, PORFIREVA A, et al. Electrochemical aptasensors based on hybrid metal-organic frameworks[J]. Sensors, 2020,20(23):6963-6996.
【11】LING P H, LEI J P, JIA L, et al. Platinum nanoparticles encapsulated metal-organic frameworks for the electrochemical detection of telomerase activity[J]. Chemical Communications, 2016,52(6):1226-1229.
【12】SHEN W J, ZHUO Y, CHAI Y Q, et al. Ce-based metal-organic frameworks and DNAzyme-assisted recycling as dual signal amplifiers for sensitive electrochemical detection of lipopolysaccharide[J]. Biosensors and Bioelectronics, 2016,83:287-292.
【13】WANG M H, HU M Y, LI Z Z, et al. Construction of Tb-MOF-on-Fe-MOF conjugate as a novel platform for ultrasensitive detection of carbohydrate antigen 125 and living cancer cells[J]. Biosensors and Bioelectronics, 2019,142:56-63.
【14】荣胜忠,张慧,邹立娜,等.金属有机骨架复合材料生物传感器检测肿瘤标志物的应用进展[J].分析试验室, 2021,40(2):233-240.
【15】CHITICARU E A, PILAN L, DAMIAN C M, et al. Influence of graphene oxide concentration when fabricating an electrochemical biosensor for DNA detection[J]. Biosensors, 2019,9(4):113-131.
【16】CHEN Y H, GUO S L, ZHAO M, et al. Amperometric DNA biosensor for Mycobacterium tuberculosis detection using flower-like carbon nanotubes-polyaniline nanohybrid and enzyme-assisted signal amplification strategy[J]. Biosensors and Bioelectronics, 2018,119:215-220.
【17】CUI M J, ZHAO Q Y, ZHANG Q, et al. Nitrogen doped chiral carbonaceous nanotube for ultrasensitive DNA direct electrochemistry, DNA hybridization and damage study[J]. Analytica Chimica Acta, 2018,1038:41-51.
【18】AI X Z, MA Q, SU X G. Multiplex DNA sensor for BRAF and BRCA detection[J]. Analytical Biochemistry, 2013,438(1):22-28.
【19】ARIFFIN E Y, LEE Y H, FUTRA D, et al. An ultrasensitive hollow-silica-based biosensor for pathogenic Escherichia coli DNA detection[J]. Analytical and Bioanalytical Chemistry, 2018,410(9):2363-2375.
【20】DEMIREL G, RZAEV Z, PATIR S, et al. Poly(N-isopropylacrylamide) layers on silicon wafers as smart DNA-sensor platforms[J]. Journal of Nanoscience and Nanotechnology, 2009,9(3):1865-1871.
【21】SU S, CAO W F, LIU W, et al. Dual-mode electrochemical analysis of microRNA-21 using gold nanoparticle-decorated MoS2 nanosheet[J]. Biosensors and Bioelectronics, 2017,94:552-559.
【22】MA J H, CHAI W X, LU J Y, et al. Coating a DNA self-assembled monolayer with a metal organic framework-based exoskeleton for improved sensing performance[J]. The Analyst, 2019,144(11):3539-3545.
【23】许永强.电化学DNA生物传感平台的构建及其应用[D].南京:南京邮电大学, 2020.
【24】王存,刘蕃鑫,惠俊敏,等.基于生物金属有机骨架封装亚甲基蓝复合材料和信号放大策略高灵敏检测microRNA-141[J].分析化学, 2020,48(9):1185-1192.
【25】BAO T, FU R B, WEN W, et al. Target-driven cascade-amplified release of loads from DNA-gated metal-organic frameworks for electrochemical detection of cancer biomarker[J]. ACS Applied Materials & Interfaces, 2020,12(2):2087-2094.
【26】SHEN W J, ZHUO Y, CHAI Y Q, et al. Cu-based metal-organic frameworks as a catalyst to construct a ratiometric electrochemical aptasensor for sensitive lipopolysaccharide detection[J]. Analytical Chemistry, 2015,87(22):11345-11352.
【27】DENG C Y, PI X M, QIAN P, et al. High-performance ratiometric electrochemical method based on the combination of signal probe and inner reference probe in one hairpin-structured DNA[J]. Analytical Chemistry, 2017,89(1):966-973.
【28】YU H, HAN J, AN S J, et al. Ce(Ⅲ,Ⅳ)-MOF electrocatalyst as signal-amplifying tag for sensitive electrochemical aptasensing[J]. Biosensors and Bioelectronics, 2018,109:63-69.
【29】WANG Z, YU H, HAN J, et al. Rare Co/Fe-MOFs exhibiting high catalytic activity in electrochemical aptasensors for ultrasensitive detection of ochratoxin A[J]. Chemical Communications, 2017,53(71):9926-9929.
【30】WU C J, WANG S F, LUO X L, et al. Adenosine triphosphate responsive metal-organic frameworks equipped with a DNA structure lock for construction of a ratiometric SERS biosensor[J]. Chemical Communications, 2020,56(9):1413-1416.
【31】DRATWA M, WYSOCZAHSKA B, ŁACINA P, et al. TERT-regulation and roles in cancer formation[J]. Frontiers in Immunology, 2020,11:929-945.
【32】ROAKE C M, ARTANDI S E. Regulation of human telomerase in homeostasis and disease[J]. Nature Reviews Molecular Cell Biology, 2020,21(7):384-397.
【33】DONG P F, ZHU L Y, HUANG J, et al. Electrocatalysis of cerium metal-organic frameworks for ratiometric electrochemical detection of telomerase activity[J]. Biosensors and Bioelectronics, 2019,138:3-13.
【34】WANG Y Q, DONG P F, HUANG J, et al. Direct electrochemistry of silver nanoparticles-decorated metal-organic frameworks for telomerase activity sensing via allosteric activation of an aptamer hairpin[J]. Analytica Chimica Acta, 2021,1184:36-46.
【35】BAUTISTA-SÁNCHEZ D, ARRIAGA-CANON C, PEDROZA-TORRES A, et al. The promising role of miR-21 as a cancer biomarker and its importance in RNA-based therapeutics[J]. Molecular Therapy-Nucleic Acids, 2020,20:409-420.
【36】HUANG B, WU G Z, PENG C X, et al. miR-126 regulates the proliferation, migration, invasion, and apoptosis of non-small lung cancer cells via AKT2/HK2 axis[J]. IUBMB Life, 2021:1-10.
【37】MA X Y, QIAN K, EJEROMEDOGHENE O, et al. A label-free electrochemical platform based on a thionine functionalized magnetic Fe-N-C electrocatalyst for the detection of microRNA-21[J]. The Analyst, 2021,146(14):4557-4565.
【38】HU M, ZHU L, LI Z Z, et al. CoNi bimetallic metal-organic framework as an efficient biosensing platform for miRNA 126 detection[J]. Applied Surface Science, 2021,542:586-597.
【39】HAO C, ZHANG G Q, ZHANG L J. Serum CEA levels in 49 different types of cancer and noncancer diseases[J]. Progress in Molecular Biology and Translational Science, 2019,162:213-227.
【40】LI J F, LIU L, AI Y J, et al. Self-polymerized dopamine-decorated Au NPs and coordinated with Fe-MOF as a dual binding sites and dual signal-amplifying electrochemical aptasensor for the detection of CEA[J]. ACS Applied Materials & Interfaces, 2020,12(5):5500-5510.
【41】CHEN M, GAN N, ZHOU Y, et al. An electrochemical aptasensor for multiplex antibiotics detection based on metal ions doped nanoscale MOFs as signal tracers and RecJf exonuclease-assisted targets recycling amplification[J]. Talanta, 2016,161:867-874.
【42】WANG S Y, HE B S, LIANG Y, et al. Exonuclease III-driven dual-amplified electrochemical aptasensor based on PDDA-Gr/PtPd@Ni-Co hollow nanoboxes for chloramphenicol detection[J]. ACS Applied Materials & Interfaces, 2021,13(22):26362-26372.
【43】HE Y Q, GAO Y, GU H W, et al. Target-induced activation of DNAzyme for sensitive detection of bleomycin by using a simple MOF-modified electrode[J]. Biosensors and Bioelectronics, 2021,178:3034-3039.
【44】ZHANG X N, ZHU M C, JIANG Y J, et al. Simple electrochemical sensing for mercury ions in dairy product using optimal Cu2+-based metal-organic frameworks as signal reporting[J]. Journal of Hazardous Materials, 2020,400:222-229.
【45】YU Y J, YU C, NIU Y Z, et al. Target triggered cleavage effect of DNAzyme:Relying on Pd-Pt alloys functionalized Fe-MOFs for amplified detection of Pb2+[J]. Biosensors and Bioelectronics, 2018,101:297-303.
【46】XIE F T, ZHAO X L, CHI K N, et al. Fe-MOFs as signal probes coupling with DNA tetrahedral nanostructures for construction of ratiometric electrochemical aptasensor[J]. Analytica Chimica Acta, 2020,1135:123-131.
【47】WEN X Y, HUANG Q W, NIE D X, et al. A multifunctional N-doped Cu-MOFs (N-Cu-MOF) nanomaterial-driven electrochemical aptasensor for sensitive detection of deoxynivalenol[J]. Molecules, 2021,26(8):2243-2254.
【48】QIU W W, GAO F, YANO N, et al. Specific coordination between Zr-MOF and phosphate-terminated DNA coupled with strand displacement for the construction of reusable and ultrasensitive aptasensor[J]. Analytical Chemistry, 2020,92(16):11332-11340.
【49】DAI G, LI Z, LUO F F, et al. Simultaneous electrochemical determination of nuc and mecA genes for identification of methicillin-resistant Staphylococcus aureus using N-doped porous carbon and DNA-modified MOF[J]. Mikrochimica Acta, 2021,188(2):39-48.
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