气相色谱-质谱法测定奶瓶中双酚A含量
GC-MS Determination of Bisphenol A in Feeding-Bottle
摘 要
提出了气相色谱-质谱法测定奶瓶中双酚A含量的方法。取剪碎的样品经二氯甲烷溶解,甲醇提取后,所得净化液中双酚A与N,O-双(三甲基硅烷基)三氟乙酰胺-三甲基氯硅烷(99+1)溶液进行衍生化反应,产物用乙酸乙酯定容。在气相色谱分离中用DB-5MS毛细管柱为固定相,在质谱分析中采用选择离子监测模式。双酚A的质量浓度在10.0~200.0 μg·L-1范围内与峰面积呈线性关系,测定下限(10S/N)为1.0 mg·kg-1。方法用于奶瓶中双酚A的测定,回收率在77.5%~95.1%之间,相对标准偏差(n=6)为3.9%。
双酚A
奶瓶
GC-MS
Bisphenol A
Feeding-bottles
Abstract
A method of GC-MS for determination of bisphenol A in feeding-bottle was proposed. The sheared sample was dissolved with CH2Cl2 and extracted with methanol, then derivatized with N,O-bis(trimethyl-silanyl)-trifluoro-acetamide-trimethylchloro silane (99+1) solution. The derivatized product was dissolved with ethyl acetate. DB-5MS capillary column was used for GC separation and selected ion monitoring mode were adopted in MS determination. Linear relationship between values of peak area and mass concentration of bisphenol A was obtained in the range of 10.0-200.0 μg·L-1, with lower limit of determination (10S/N) of 1.0 mg·kg-1. The proposed method was applied to the analysis of feeding-bottle, giving values of recovery in the range of 77.5%-95.1% and RSD (n=6) of 3.9%.
中图分类号 O657.63
所属栏目 工作简报
基金项目 广东省医学科研基金(A2011062)
收稿日期 2012/5/11
修改稿日期
网络出版日期
作者单位点击查看
联系人作者李少霞(lishaox@tom.com)
备注李少霞(1975-),女,广东佛山人,硕士,主要从事食品安全风险监测。
引用该论文: LI Shao-xia,HUANG Wei-xiong,YU Sheng-bing,LIU Rui,CHEN Ming,YAO Jing. GC-MS Determination of Bisphenol A in Feeding-Bottle[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2013, 49(6): 679～682
李少霞,黄伟雄,余胜兵,刘锐,陈明,姚敬. 气相色谱-质谱法测定奶瓶中双酚A含量[J]. 理化检验－化学分册, 2013, 49(6): 679～682
被引情况:
【1】凌绍明,欧阳辉祥,黄宝敬, "基于固绿褪色反应的分光光度法测定双酚A的含量",理化检验－化学分册 52, 625-628(2016)
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参考文献
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【11】丁红春,李建林,徐逸云,等.婴幼儿奶瓶中迁移双酚A的高效液相色谱-电喷雾串联质谱检测方法研究［J］.化学分析计算, 2010,19(5):42-45.
【12】吴莉莉,沈兵,应晓虹,等.沉淀分离-气相色谱法测定聚氯乙烯塑料制品中的磷酸甲苯酯类增塑剂［J］.分析化学, 2012,40(4):617-621.
【2】唐熙,陈高群,梁鸣,等.气相色谱法测定塑料奶瓶中迁移出的双酚A［J］.福建分析测试, 2010,19(4):13-17.
【3】卫碧文,缪俊文,于文佳.气相色谱-质谱法分析食品包装材料中双酚A［J］.分析试验室, 2009,28(1):107-109.
【4】SUNG H N, YOUNG M S, MAN G K. Bisphenol a migration from polycarbonate baby bottle with repeated use［J］. Chemosphere, 2010,79:949-952.
【5】KUBWABOA C, KOSARACA I, STEWARTA B, et al. Migration of bisphenol a from plastic baby bottles, baby bottle liners and reusable polycarbonate drinking bottles［J］. Food Additives and Contaminants, 2009,26(6):928-937.
【6】彭青枝,李涛,潘思轶.食品包装材料聚碳酸酯中双酚A残留量的测定［J］.中国卫生检验杂志, 2009,19(4):798-799.
【7】宣栋梁,陈静.固相萃取-高效液相色谱法测定婴幼儿奶瓶中溶出的双酚A［J］.现代预防医学, 2008,35(23):4663-4665.
【8】郭春海,陈瑞春,赵安康,等.聚碳酸酯奶瓶中双酚A单体向食品模拟物迁移规律的研究［J］.食品科学, 2011,32(12):246-250.
【9】孙汉文,李挥,高文惠,等.食品包装材料中双酚A迁移量的测定［J］.食品科学, 2012,33(2):235-239.
【10】DUCK S L, SEUNG J K, KYU B K, et al. Potential risk of bisphenol a migration from polycarbonate containers after heating, boiling, and microwaving［J］. Journal of Toxicology and Environmental Health, 2009,72:1285-1291.
【11】丁红春,李建林,徐逸云,等.婴幼儿奶瓶中迁移双酚A的高效液相色谱-电喷雾串联质谱检测方法研究［J］.化学分析计算, 2010,19(5):42-45.
【12】吴莉莉,沈兵,应晓虹,等.沉淀分离-气相色谱法测定聚氯乙烯塑料制品中的磷酸甲苯酯类增塑剂［J］.分析化学, 2012,40(4):617-621.
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