提出了气相色谱-质谱法测定指甲油中17种挥发性溶剂含量的方法。样品经甲醇提取,提取液经0.22 μm有机针头过滤器过滤。在气相色谱分离中用DB-624毛细管柱为固定相,在质谱分析中采用全扫描和选择离子监测模式。17种挥发性溶剂的峰面积与质量分数在3.2~400 g·kg-1范围内呈线性关系,检出限(3S/N)在0.14~1.60 g·kg-1之间。用标准加入法测得17种挥发性溶剂的回收率在89.7%~106%之间,测定值的相对标准偏差(n=6)在0.96%~6.6%之间。

GC-MS was applied to the determination of 17 volatile organic solvents in nail polish. The sample was extracted with methanol, and the extract was filtered with organic needle filter of 0.22 μm. DB-624 capillary column was used as the stationary phase in GC separation, and full-scanning mode as well as selected ion monitoring mode were adopted in MS determination. Linear relationship between values of peak area and mass fraction of 17 volatile solvents were obtained in the same range of 3.2-400 g·kg-1, with detection limits (3S/N) in the range of 0.14-1.60 g·kg-1. Tests for recovery was made by standard addition method, and values of recovery found were in the range of 89.7%-106% with RSD′s (n=6) in the range of 0.96%-6.6%.