生物医用镁合金耐蚀性的研究进展
Progress in Research on Corrosion Resistance of Biomedical Magnesium Alloys
摘 要
镁合金具有优良的机械性能，与人体生物相容性好，尤其是具有可生物降解的特点，是一种很有前途的生物降解医用材料。综述了生物医用镁合金的研究进展，并阐明了其在人体内的降解机理及提高镁合金耐蚀性的改进方法，详细介绍了研究镁合金耐蚀性的方法，并指明了研究中存在的问题和未来发展方向。
耐腐蚀性能
生物材料
医用材料
magnesium alloy
corrosion resistance
biological material
medical material
Abstract
Magnesium alloy is a kind of very promising biodegradable medical material because of excellent mechanical properties, biocompatibility, especially biodegradable characteristics. The process in research on biomedical magnesium alloys are reviewed. The degradation mechanism in vivo, and the methods for improving the corrosion resistance of magnesium alloys are explained. Research methods for corrosion resistance of magnesium alloys are introduced. And the problems and development trends in research are pointed out.
中图分类号 TG132.3 DOI 10.11973/fsyfh-201608013
所属栏目 专论
基金项目 国家自然科学基金研究项目(51374068); 辽宁省自然科学基金项目(2014020033)
收稿日期 2015/5/19
修改稿日期
网络出版日期
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联系人作者崔彤(ct114928@163.com)
备注崔 彤(1968-),副教授,博士,从事金属生物材料、高性能材料领域的研究工作
引用该论文: ZHANG Lu,CUI Tong,SHI Xu-chen. Progress in Research on Corrosion Resistance of Biomedical Magnesium Alloys[J]. Corrosion & Protection, 2016, 37(8): 666
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参考文献
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【30】方元. 生物可降解镁合金支架基体材料腐蚀性能的研究[D]. 兰州:兰州理工大学,2010.
【31】WALTER R,KANNAN M B. In vitro degradation behaviour of WE54 magnesium alloy in simulated body fluid[J]. Material Letters,2011,65:748-750.
【32】BRAR H S,WONG J,MANUCL M V. Investigation of the mechanical and degradation properties of Mg-Sr and Mg-Zn-Sr alloys for use as potential biodegradable implant materials[J]. J Mech Behav Biomed Mater,2012,7:87-90.
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【34】高亚丽,熊党生,王存山,等. 医用镁合金激光熔覆羟基磷灰石涂层初探[J]. 特种铸造及有机合金,2009,24(4):305-307.
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【36】李琮,李明照,王跃琪,等. Nd对挤压态AZ31镁合金耐腐蚀性能的影响[J]. 稀有金属材料与工程,2011,40(1):157-160.
【37】YIN D S,ZHANG E L,ZENG S Y. Effect of Zn on mechanical property and corrosion property of extruded Mg-Zn-Mn alloy[J]. Trans Nonferrous Metals Soc China,2008,18(4):763-765.
【38】江民华. 稀土元素Sm对AM60镁合金显微组织和耐腐蚀性能的影响[J]. 热加工工艺,2015,44(4):88-91.
【39】曹楚男,张鉴清,曹和发. Mg-Al系镁合金及稀土元素(Ce,La)合金化后微观结构和腐蚀行为的研究[D]. 浙江:浙江大学,2012：2.
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【41】ZHOU X H,HUANG Y W,WEI Z L,et al. Improvement of corrosion resistance of AZ91D magnesium alloy by holmium addition[J]. Corrosion Science,2006,48(12):4223-4226.
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【43】FAN Y,WU G H,GAO H T,et al. Influence of lanthanum on the microstructure,mechanical property and corrosion resistance of magnesium alloy[J]. Materials Science,2006,41(17):5409-5411.
【2】LIU Cheng-long,XIN Yun-chang,TANG Guo-yi,et al. Influence of heat treatment on degadation behavior of biodegradable diecast AZ63 magnesium alloy in simulated body fluid[J]. Materials Science and Engineering:A,2007,456(1/2):350-357.
【3】ZHONG Li-ping,HU Ze-hao,LI Li-jun,et al. Research progress on high-property metal materials[J]. Heat Treatment of Metal,2003,28(11):11-14.
【4】NAGELS J,STOKDIJK M,ROZING P M. Stress shielding and bone resorption in shoulder arthroplasty[J]. Journal of Shoulder and Elbow Surgery,2003,12(1):35-39.
【5】SONG Guang-ling. Control of biodegradation of biocompatible magnesium alloys[J]. Corrosion Science,2007,49(4):1696-1701.
【6】WITTE F,FISCHER J,NELLESEN J,et al. In vitro and in vivo corrosion measurements of magnesium alloys[J]. Biomaterials,2006,27(7):1013-1018.
【7】卫英慧,许并社. 镁合金腐蚀防护的理论与实践[M]. 北京:冶金工业出版社,2007.
【8】欧阳春,雷霆,王丽,等. Mg-Zn-Ca三元镁合金生物材料的腐蚀行为[J]. 中国有色金属学报,2010,20(5):891-897.
【9】谭小伟,高家诚,王勇,等. 医用纯镁的热处理试验研究[J]. 科技导报,2006,24(2):67-69.
【10】赵鸿金,张迎晖,康永林,等. 镁合金阻燃元素氧化热力学及氧化物物性分析[J]. 特种铸造及有色金属，2006,26(6):340-344.
【11】李龙川,高家诚,王勇. 医用镁合金的腐蚀行为与表面改性[J]. 材料导报,2003,17(10):29-32.
【12】黄晶晶,杨柯. 镁合金的生物医用研究[J]. 材料导报,2006,20(4):67-69.
【13】张汉茹,郝远. AZ91D镁合金在含Cl-溶液中腐蚀机理的研究[J]. 铸造设备研究,2007(3):19-24.
【14】WITTE F,KAESEB V,HAFERKAMP H,et al. In vivo corrosion of four magnesium alloys and the associated bone response[J]. Bio Materials,2005,26(17):3557-3563.
【15】刘通,张永君. 医用镁合金降解控制技术的研究进展[J]. 材料导报,2010,24(11):86-89.
【16】李华伦,胡锐,曲卫涛,等. 镁及镁合金的高纯净化[J]. 特种铸造及有色合金,2009(增1):87-89.
【17】高家成,伍沙,乔丽英,等. 镁及镁合金在仿生体液中的腐蚀降解行为[J]. 基础医学,2007,11(18):3584-3586.
【18】任伊宾,黄晶晶,杨柯,等. 纯镁的生物腐蚀研究[J]. 金属学报,2005,41(11):1228-1232.
【19】CAO P,QIAN M,STJOHN D H. Native grain refinement of magnesium alloys[J]. Scripta Mater,2005,53:841-843.
【20】尹冬松,张二林,曾松岩. 生物医用镁合金腐蚀的研究现状[J]. 铸造设备研究,2008(4):38-41.
【21】徐卫军,马颖,吕维玲,等. 镁合金腐蚀的影响因素[J]. 腐蚀与防护,2007,28(4):163-166.
【22】YUMIKO N,YUKARI T,YASUHIDE T,et al. Differences in behavior among the chlorides of seven rare earth elements administered intravenously to rats[J]. Fundam Apl Toxicol,1997,37:106-116.
【23】YANG W,ZHANG P,LIU J,et al. Effect of long-term intake of Y3+ in drinking water on gene expression brains of rats[J]. J Rare Earth,2006,24(3):369-372.
【24】贾冬梅,宋义全. Ca对医用Mg-1Zn-xCa合金材料在模拟体液中腐蚀行为的研究[J]. 内蒙古科技大学学报,2014,32(2):113-127.
【25】耿丽彦,宋义全,张永虎. Zn含量对生物医用镁合金耐Hank′s模拟体液腐蚀的影响[J]. 材料保护,2012,45(8):28-32.
【26】周世杰,黄楠,龚旭,等. Mg-Zn-Mn、Mg-Zn-Sr三元生物镁合金的制备与研究[J]. 轻金属,2013,11(10):49-52.
【27】余琨,雷路,陈良建. 新型镁合金在生理体液环境下腐蚀行为评价[J]. 金属功能材料,2011,18(2):32-35.
【28】CHANG Jian-wei,GUO Xing-wu,FU Peng-hui,et al. Effect of heat treatment on corrosion and electrochemical behaviour of Mg-3Nd-0.2Zn-0.4Zr (wt%) alloy[J]. Electrochimica Acta,2007,52(9):3160-3167.
【29】ZHAO Y,WU G,JIANG J,et al. Improved corrosion resistance and cytocompatibility of magnesium alloy by two-stage cooling in thermal treatment[J]. Corrosion Science,2012,59:360-363.
【30】方元. 生物可降解镁合金支架基体材料腐蚀性能的研究[D]. 兰州:兰州理工大学,2010.
【31】WALTER R,KANNAN M B. In vitro degradation behaviour of WE54 magnesium alloy in simulated body fluid[J]. Material Letters,2011,65:748-750.
【32】BRAR H S,WONG J,MANUCL M V. Investigation of the mechanical and degradation properties of Mg-Sr and Mg-Zn-Sr alloys for use as potential biodegradable implant materials[J]. J Mech Behav Biomed Mater,2012,7:87-90.
【33】LIU De-bao,HUANG Yan,PRANGNELL P B. Microstructure and performance of a biodegradable Mg-1Ca-2Zn-1TCP composite fabricated by combined solidification and deformation processing[J]. Materials Letters,2012,82:7-9.
【34】高亚丽,熊党生,王存山,等. 医用镁合金激光熔覆羟基磷灰石涂层初探[J]. 特种铸造及有机合金,2009,24(4):305-307.
【35】宋光铃. 镁合金腐蚀与防护[M]. 北京:化学工业出版社,2006:94.
【36】李琮,李明照,王跃琪,等. Nd对挤压态AZ31镁合金耐腐蚀性能的影响[J]. 稀有金属材料与工程,2011,40(1):157-160.
【37】YIN D S,ZHANG E L,ZENG S Y. Effect of Zn on mechanical property and corrosion property of extruded Mg-Zn-Mn alloy[J]. Trans Nonferrous Metals Soc China,2008,18(4):763-765.
【38】江民华. 稀土元素Sm对AM60镁合金显微组织和耐腐蚀性能的影响[J]. 热加工工艺,2015,44(4):88-91.
【39】曹楚男,张鉴清,曹和发. Mg-Al系镁合金及稀土元素(Ce,La)合金化后微观结构和腐蚀行为的研究[D]. 浙江:浙江大学,2012：2.
【40】刘楚明,葛位维,李慧中,等. Er对铸态AZ91镁合金显微组织和耐腐蚀性能的影响[J]. 中国有色金属学报,2009,196(5):847-850.
【41】ZHOU X H,HUANG Y W,WEI Z L,et al. Improvement of corrosion resistance of AZ91D magnesium alloy by holmium addition[J]. Corrosion Science,2006,48(12):4223-4226.
【42】LIU W J,CAO F H,CHANG L R,et al. Effect of rare earth element Ce and La on corrosion behavior of AM60 magnesium alloy[J]. Corrosion Science,2009,51(6):1334-1337.
【43】FAN Y,WU G H,GAO H T,et al. Influence of lanthanum on the microstructure,mechanical property and corrosion resistance of magnesium alloy[J]. Materials Science,2006,41(17):5409-5411.
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