称取样品0.100 0 g，用水溶解后，根据被测物浓度不同加水定量稀释至合适浓度。在高效液相色谱分离中，选择PRP-X100为分离柱，由于固定相上键合有二乙烯基苯/三乙胺聚合物，对氯铂酸和卡铂的分离效果较好。用60 mmol·L^-1硝酸铵溶液（预先用稀氨水或稀硝酸调节其酸度至pH 5.5）为流动相，按等梯度程序进行洗脱。分离后的洗脱液按质谱仪器的工作条件进行测定。结果表明：氯铂酸和卡铂的线性范围依次为1.00~100 μg·L^-1和500.0~1 000 μg·L^-1；检出限（3S/N）依次为0.1，0.01 μg·L^-1。按标准加入法在实际样品基础上进行回收试验，测得氯铂酸的回收率为90.0%~98.8%，卡铂的回收率为98.5%~99.2%，两者测定值的相对标准偏差（n=6）依次为2.7%~3.4%和2.1%~2.8%。应用上述方法进行实际样品分析时还发现，当卡铂的检测量为1 mg·L^-1时，未检测到氯铂酸，故该方法无需富集就能达到痕量铂的测定。

A portion of the sample (0.100 0 g) was dissolved in water and diluted to an appropriate volume according to the concentration of the analyte in sample. The ion-exchange column PRP-X100 was chosen as separation column, which was proved to have high efficiency in separation of chloroplatinic acid and carboplatin, due to bonding of polymer of divinylbenzene/triethylamine on the stationary phase. 60 mmol·L^-1 NH₄NO₃ solution (pre-adjusted its acidity to pH 5.5 with dil. NH₃·H₂O or dil. HNO₃) was used as mobile phase in the gradient elution program. Analyte in respective eluate was then determined by ICP-MS according to the prescribed procedure. As shown by the results, linearity ranges for chloroplatinic acid and carboplatin were found between 1.00 and 100 μg·L^-1 and between 500.0 and 1 000 μg·L^-1 with detection limits (3S/N) of 0.1 μg·L^-1 and 0.01 μg·L^-1respectively. Testes for recovery were performed by standard addition method using a substantial sample as matrix, giving values of recovery of 90.0%-98.8% for chloroplatinic acid and of 98.5%-99.2% for carboplatin. Values of RSDs (n=6) found was 2.7%-3.4% for chloroplatinic acid and 2.1%-2.8% for carbonplatin. It was found that in the analysis of a substantial sample by the proposed method, as the concentration of carboplatin found was 1 mg·L^-1, H₂[PtCl₆] was not inspected in the same sample. Hence, inspection of traces of platinum(Ⅳ) was attained directly in the sample solution without any enrichment manipulation.