基于光谱净信号算法的紫外分光光度法快速同时测定复方盐酸阿米洛利片中的盐酸阿米洛利和氢氯噻嗪
Fast and Simultaneous Determinations of Amiloride Hydrochloride and Hydrochlorothiazide in Compound Amiloride Hydrochlorothiazide Tablets by UV Spectrophotometry with Using Spectral Net Signal Algorithm
摘 要
结合光谱净信号算法，对紫外光谱相互干扰的复方盐酸阿米洛利片中盐酸阿米洛利和氢氯噻嗪进行快速同时测定。在240~400 nm内，通过光谱净信号算法计算盐酸阿米洛利和氢氯噻嗪的光谱净信号，两种组分的质量浓度与其光谱净信号分别在1.6~2.4 mg·L-1和16~24 mg·L-1内呈线性关系。盐酸阿米洛利和氢氯噻嗪的平均回收率分别为105%~106%和104%~105%。测定结果的相对标准偏差（n=5）分别为0.77%，0.69%。
紫外分光光度法
盐酸阿米洛利
氢氯噻嗪
spectral net signal
UV spectrophotometry
amiloride hydrochloride
hydrochlorothiazide
Abstract
The mutual interference of the UV-spectra of the two effective components amiloride hydrochloride and hydrochlorothiazide contained in the compound amiloride hydrochlorothiazide tablets was solved by the application of the spectral net signal algorithm, and fast and simultaneous determination of the two effective components was performed. In the UV-spectral range of 240-400 nm, the net spectral signals of amilolide hydrochloride and hydrochlorothiazide were calculated by the spectral net signal algorithm, and linear relationships between net spectral signals and mass concentration of the two components were found in ranges of 1.6-2.4 mg·L-1 and 16-24 mg·L-1, respectively. Average recoveries of the two components were found in ranges of 105%-106% and 104%-105%, with RSD (n=5) of 0.70% and 0.69%, respectively.
中图分类号 O675.32 DOI 10.11973/lhjy-hx201909013
所属栏目 工作简报
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收稿日期 2019/1/1
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备注何欢欢,硕士研究生,主要从事药物质量评价和控制
引用该论文: HE Huanhuan,YOU Sijia,ZHANG Chen,LIU Wenjuan,XIE Hongping. Fast and Simultaneous Determinations of Amiloride Hydrochloride and Hydrochlorothiazide in Compound Amiloride Hydrochlorothiazide Tablets by UV Spectrophotometry with Using Spectral Net Signal Algorithm[J]. Physical Testing and Chemical Analysis part B:Chemical Analysis, 2019, 55(9): 1050～1054
何欢欢,游思佳,张晨,刘文娟,谢洪平. 基于光谱净信号算法的紫外分光光度法快速同时测定复方盐酸阿米洛利片中的盐酸阿米洛利和氢氯噻嗪[J]. 理化检验－化学分册, 2019, 55(9): 1050～1054
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【5】陈久艳,方敏,吴再珍,等.基于近红外光谱测定复方盐酸阿米洛利片有效成分的含量[J].中国药房, 2013,24(9):828-830.
【6】林敏玲,吴定丽,吴云妹,等.近红外光谱法同时检测复方卡托普利片中卡托普利和氢氯噻嗪的含量[J].化工技术与开发, 2019,48(5):46-50.
【7】唐海姣,匡艳辉,张偲偲,等.复方丹参片丹酚酸B和冰片近红外光谱测定和相关性模型建立[J].中国中药杂志, 2018,43(14):2857-2862.
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【10】HE Z H, MA Z H, LUAN J M, et al. An active learning representative subset selection method using net analyte signal[J]. Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy, 2018,196:311-316.
【11】闵晓琳,刘蓉,傅博,等.双光路测量结合净信号处理方法在葡萄糖浓度定量分析中的应用[J].光谱学与光谱分析, 2017,37(9):2943-2947.
【12】HE Z H, LIU L N, LI M C, et al. Improving specific interval accuracy in multivariate calibration using a net analyte signal-based sample selection method[J]. Vibrational Spectroscopy, 2017,92:1-8.
【13】BENVIDI A, NIKMANESH M, DEHGHAN T M, et al. A comparative study of various electrochemical sensors for hydrazine detection based on imidazole derivative and different nano-materials of MCM-41, RGO and MWCNTs:Using net analyte signal (NAS) for simultaneous determination of hydrazine and phenol[J]. Journal of Electroanalytical Chemistry, 2017,787:145-157.
【14】HEGAZY M A M, ABBAS S S, ZAAZAA H E S. Resolution of overlapped quaternary spectral bands by net analyte signal based methods; an application to different combinations in tablets and capsules[J]. Journal of Analytical Chemistry, 2015,70(4):450-458.
【15】ZHANG H G, LU J G. Local regression algorithm based on net analyte signal and its application in near infrared spectral analysis[J]. Spectroscopy and Spectra Analysis, 2016,36(2):384-387.
【16】KOMPANY-ZAREH M, MIRZAEI S. Spectrophotometric resolution of ternary mixtures of pseudoephedrine hydrochloride, dextromethorphan hydrobromide, and sodium benzoate in syrups using wavelength selection by net analyte signals calculated with hybrid linear analysis[J]. Analytica Chimica Acta, 2004,526(1):83-94.
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