建立了加速溶剂萃取（ASE）-凝胶渗透色谱法（GPC）净化-气相色谱-串联质谱法（GC-MS/MS）测定土壤中的7种农药（五氯硝基苯、多效唑、腐霉利、甲霜灵、醚菊酯、啶虫脒和咪鲜胺）残留量的分析方法。随机采集种植土壤样品，于35 ℃烘干压碎后过2 mm孔径筛；称取过筛后的土壤样品10 g于加速溶剂萃取池中，以体积比为1∶1的丙酮-正己烷混合液为萃取剂，采用ASE反复萃取3次；将收集到的萃取液全部转移至GPC净化瓶中，经GPC净化后氮吹至近干，残渣用1 mL正己烷溶解，0.45 μm微孔滤膜过滤，滤液进GC-MS/MS仪，多反应监测（MRM）模式分析，外标法定量。结果显示：7种农药的质量浓度在0.04~4.0 mg·L^-1内与其峰面积呈线性关系，检出限（3S/N）为0.002~0.007 mg·kg^-1；对空白样品进行3个浓度水平的加标回收试验，7种农药的回收率为88.9%~104%，测定值的相对标准偏差（n=6）均小于4.0%。方法用于实际样品分析，检出了腐霉利和啶虫脒，检出量分别为0.010，0.005 mg·kg^-1。

A method of gas chromatography tandem mass spectrometry (GC-MS/MS) coupled with accelerated solvent extraction (ASE) and gel permeation chromatography (GPC) purification for the determination of 7 pesticides (quintozene, paclobutrazol, procymidone, metalaxyl, ethofenprox, acetamiprid and prochloraz) residues in soil was established. Soil samples were randomly collected and passed by 2 mm sieve after drying at 35 ℃and crushing. Screened soil sample of 10 g was placed in the accelerated solvent extraction tank, and extracted repeatedly 3 times by ASE with extraction solvent of a mixture of acetone and hexane at volume ratio of 1∶1. The extracted solution was purified by GPC and blown to nearly dryness by nitrogen. The residue was dissolved by hexane of 1 mL and filtered by 0.45 μm microporous membrane, then MRM mode was adopted in GC-MS/MS analysis, and external standard was used for quantification. As found by results, linearity relationships between mass concentrations of 7 pesticides and their peak areas were kept in the range of 0.04-4.0 mg·L^-1, with detection limits (3S/N) in the range of 0.002-0.007 mg·kg^-1. Recovery test was made on blank samples at 3 concentration levels, giving recovery of 7 pesticides in the range of 88.9%-104%, and RSDs (n=6) of the determined values less than 4.0%. The method was used for the analysis of actual samples, and promolide and acetamiprid were detected, with detection amounts of 0.010, 0.005 mg·kg^-1, respectively.