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    HUANG Ke-jian, PAN Zhi-wen, LIN Cui-wu, LI Hong-sen, LIU Xiao-feng, LI Lu, LUO Zheng-jian, CHEN Er-lian. GC-MS with HS-SPME Determination of Methadone and Its Main Metabolite in Urine[J]. PHYSICAL TESTING AND CHEMICAL ANALYSIS PART B:CHEMICAL ANALYSIS, 2009, 45(8): 962-964.
    Citation: HUANG Ke-jian, PAN Zhi-wen, LIN Cui-wu, LI Hong-sen, LIU Xiao-feng, LI Lu, LUO Zheng-jian, CHEN Er-lian. GC-MS with HS-SPME Determination of Methadone and Its Main Metabolite in Urine[J]. PHYSICAL TESTING AND CHEMICAL ANALYSIS PART B:CHEMICAL ANALYSIS, 2009, 45(8): 962-964.
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    GC-MS with HS-SPME Determination of Methadone and Its Main Metabolite in Urine

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    • Received Date: April 11, 2008
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    • GC-MS with HS-SPME was applied to the determination of contents of methadone and its main metabolite EDDP in urine.Influtential factors to extraction efficiency,including extracting time,extracting temperature,pH value,and ionic strength were studied and optimized.SKF525A was used as internal standard,and the ions with m/z 277,72 and 86 was selected as quantitative ions for the determination of EDDP,methadone and SKF525A,respectively.Linearity ranges for both methadone and EDDP were between 0.01-1.0 mg·L-1,with RSD′s (n=5) less than 9.0%.The values of recovery of methadone and EDDP found by standard addition method were 104.2% and 97.6% respectively.
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      • References (7)
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